The Latvian Football Cup 2010–11 was the 69th edition of the Latvian football knockout tournament. The winners will qualify for the second qualifying round of the UEFA Europa League 2011–12.
Into this round entered the six winners of the previous round and nine clubs from the Latvian First League. Six of the clubs were drawn into three matches before the round began to reduce the number of clubs in this round to 12. These matches took place on 29 August and 9 September 2010.
Entering this round were the six winners from the previous round and the ten clubs from the Latvian Higher League. The draw for this round occurred on 20 September 2010. These matches were played between 26 September 2010 and 20 October 2010.