CopA-like RNA

CopA-like RNA
CopA-like RNA
	Predicted secondary structure and sequence conservation of CopA
Identifiers
Symbol	CopA
Rfam	RF00042
Other data
RNA type	Gene; antisense
Domain(s)	Bacteria
SO	SO:0000644
PDB structures	PDBe

CopA-like RNA is a family of non-coding RNAs found on the R1 plasmid.

In several groups of bacterial plasmids, antisense RNAs regulate copy number through inhibition of replication initiator protein synthesis. These RNAs are characterised by a long hairpin structure interrupted by several unpaired nucleotides or bulged loops. In plasmid R1, the inhibitory complex between the antisense RNA (CopA) and its target mRNA (CopT) is characterised by a four-way junction structure and a side-by-side helical alignment.^[1]^[2]^[3]

References

^ Nordgren, S; Slagter-Jager JG; Wagner GH (2001). "Real time kinetic studies of the interaction between folded antisense and target RNAs using surface plasmon resonance". J Mol Biol. 310 (5): 1125–1134. doi:10.1006/jmbi.2001.4802. PMID 11502000.
^ Gerhart E, Wagner H, Nordström K (1986). "Structural analysis of an RNA molecule involved in replication control of plasmid R1". Nucleic Acids Res. 14 (6): 2523–2538. doi:10.1093/nar/14.6.2523. PMC 339680. PMID 2421250.
^ Jelloul N, Bouzouita H, Belkahia A (1979). "[Significance of impedance tests in childhood deafness]". Tunis Med. 57 (4–5): 236–240. PMID 555093.