Medication for the treatment of HIV/AIDS
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Liparetrini .
Pharmaceutical compound
Efavirenz/lamivudine/tenofovir (EFV/3TC/TDF ), sold under the brand name Symfi among others, is a fixed-dose combination antiretroviral medication for the treatment of HIV/AIDS .[ 1] [ 2] [ 3] It combines efavirenz , lamivudine , and tenofovir disoproxil .[ 3] As of 2019[update] , it is listed by the World Health Organization as an alternative first line option to dolutegravir/lamivudine/tenofovir .[ 4] It is taken by mouth .[ 1] [ 2] [ 3]
Side effects can include joint pain, sleepiness, headaches, depression, trouble sleeping, and itchiness.[ 3] Severe side effects may include depression , psychosis , or osteonecrosis .[ 3] In those with a history of epilepsy , it may increase the frequency of seizures .[ 3] Greater care should also be taken in those with kidney problems .[ 3] Its use during pregnancy appears to be unsafe.[ 1] [ 2]
It is on the World Health Organization's List of Essential Medicines .[ 5] The combination received tentative approval in the United States in 2014,[ 6] and was granted approval in February 2018.[ 7] [ 8] Its availability and importance is supported by Medecins Sans Frontieres .[ 3] It is available as a generic medication .[ 9] [ 10] [ 11]
References
^ a b c d "Symfi- efavirenz, lamivudine and tenofovir disoproxil fumarate tablet, film coated" . DailyMed . Retrieved 25 September 2021 .
^ a b c d "Symfi Lo- efavirenz, lamivudine and tenofovir disoproxil fumarate tablet, film coated" . DailyMed . Retrieved 25 September 2021 .
^ a b c d e f g h "Efavirenz + lamivudine + tenofovir disoproxil fumarate (Addition) -- Adults" . World Health Organization (WHO) . Archived from the original on October 26, 2015.
^ World Health Organization (July 2019). Policy brief: update of recommendations on first- and second-line antiretroviral regimens . World Health Organization. hdl :10665/325892 . WHO/CDS/HIV/19.15. License: CC BY-NC-SA 3.0 IGO.
^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019 . Geneva: World Health Organization. hdl :10665/325771 . WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^ "HIV/AIDS History of Approvals - HIV/AIDS Historical Time Line 2010 - 2015" . U.S. Food and Drug Administration (FDA) . Archived from the original on February 27, 2016. Retrieved 13 December 2017 .
^ "Drug Approval Package: Symfi Lo (efavirenz, lamivudine and tenofovir disoproxil fumarate)" . U.S. Food and Drug Administration (FDA) . 9 October 2018. Archived from the original on April 15, 2021. Retrieved 15 August 2020 .
^ "Drug Approval Package: Symfi (efavirenz, lamivudine and tenofovir disoproxil fumarate)" . U.S. Food and Drug Administration (FDA) . 24 November 2018. Retrieved 15 August 2020 .[dead link ]
^ "Office of Generic Drugs 2020 Annual Report" . U.S. Food and Drug Administration (FDA) . Retrieved 12 February 2021 .[dead link ]
^ "Efavirenz, Lamivudine, and Tenofovir Disoproxil Fumarate: FDA-Approved Drugs" . U.S. Food and Drug Administration (FDA) . Archived from the original on October 19, 2020. Retrieved 25 September 2021 .
^ "Efavirenz, Lamivudine, and Tenofovir Disoproxil Fumarate: FDA-Approved Drugs" . U.S. Food and Drug Administration (FDA) . Archived from the original on October 19, 2020. Retrieved 25 September 2021 .
External links