The second ODI, originally scheduled to be played on 11 January 2022, was postponed after Ireland captain Andrew Balbirnie, wicket-keeper Lorcan Tucker and interim head coach David Ripley tested positive for COVID-19.[9] On 11 January 2022, both cricket boards agreed to reschedule the remaining fixtures, with the one-off T20I match being cancelled.[10] With Balbirnie ruled out of the remaining matches, Paul Stirling was named as Ireland's captain for the second and third ODIs.[11]
Ahead of the ODI series, Ireland played a 50-over tour match against Jamaica, losing the fixture by five wickets.[12] The West Indies won the first ODI match by 24 runs,[13] with Shamarh Brooks on debut top-scoring with 93.[14] The second ODI was shortened due to rain,[15] with Ireland winning the match by five wickets to level the series.[16] Ireland won the third and final ODI by two wickets to win the series 2–1.[17] Other than Afghanistan and Zimbabwe, it was Ireland's first ODI series win against a Test side.[18] It was also Ireland's first ODI series win away from home against an ICC Full Member team.[19]
Cricket West Indies named Keacy Carty and Sheldon Cottrell as reserves in their ODI squad, with Jayden Seales, Alzarri Joseph and Devon Thomas named as reserves in their T20I squad.[24]Simi Singh and Ben White were both ruled out of Ireland's squad for the first ODI after providing positive COVID-19 tests.[25] Singh and White were later ruled out of the rest of the series,[26] after returning another positive test for COVID-19.[27] Ireland's Paul Stirling and Shane Getkate also missed the first ODI, after they had to remain in the United States following positive COVID-19 tests, but rejoined the squad ahead of the second ODI.[28]Andrew Balbirnie and Lorcan Tucker tested positive for COVID-19 ahead of the second ODI, resulting in the match being postponed.[29]
