Multiple sclerosis functional composite

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The Multiple Sclerosis Functional Composite (MSFC) is a clinical trial outcome measure of assessing the severity of multiple sclerosis primarily used in research.^[1] The score is based on a combination of timed tests of walking, arm function, and cognitive ability.^[1] It was developed over two years from 1994 to 1996 by the National Multiple Sclerosis Society.^[1][2]

MSFC was developed to improve the standard measure of MS disability for clinical trials and to create a multidimensional metric of overall MS clinical status. The evaluation includes a three-part performance scale:

• Timed 25-Foot Walk (T25FT) - assessment of leg function by moving a short walking distance
• 9-Hole Peg Test (9HPT) - assessment of arm function using breadboard test
• Paced Auditory Serial Addition test (PASAT) - attention/concentration test to assess cognitive functions

An integrated MSFC score is calculated using z-scores.^[3]