PIK3C2B

PIK3C2B
Identifiers
Aliases	PIK3C2B, C2-PI3K, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
External IDs	OMIM: 602838; MGI: 2685045; HomoloGene: 20582; GeneCards: PIK3C2B; OMA:PIK3C2B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	204,494,805 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	133,036,425 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; inferior ganglion of vagus nerve; ; gingival epithelium; ; pylorus; ; nipple; ; vena cava; ; ventral tegmental area; ; epithelium of nasopharynx; ; visceral pleura; ; superficial temporal artery;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; tail of embryo; ; skeletal muscle tissue; ; striatum of neuraxis; ; genital tubercle; ; heart; ; muscle of thigh; ; colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; lipid kinase activity; 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; kinase activity; protein binding; phosphatidylinositol binding; ATP binding;
Cellular component	phosphatidylinositol 3-kinase complex; membrane; intracellular membrane-bounded organelle; plasma membrane; endocytic vesicle; endoplasmic reticulum; nucleus; nucleoplasm; cytosol; cytoplasm;
Biological process	protein kinase B signaling; phosphorylation; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-mediated signaling; cellular response to starvation; phosphatidylinositol-3-phosphate biosynthetic process; autophagosome organization; macroautophagy; phosphatidylinositol 3-kinase signaling; cell migration; biological process; phosphatidylinositol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	5287
	240752
	ENSG00000133056
	ENSMUSG00000026447
	O00750
	n/a
	NM_002646; NM_001377334; NM_001377335
	NM_001099276
	NP_002637; NP_001364263; NP_001364264
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide is an enzyme that in humans is encoded by the PIK3C2B gene.^[5]^[6]^[7]

Function

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmannin. The C2 domain of this protein was shown to bind phospholipids but not Ca²⁺, which suggests that this enzyme may function in a calcium-independent manner.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133056 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026447 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Brown RA, Ho LK, Weber-Hall SJ, Shipley JM, Fry MJ (Apr 1997). "Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K". Biochemical and Biophysical Research Communications. 233 (2): 537–44. doi:10.1006/bbrc.1997.6495. PMID 9144573.
^ Arcaro A, Volinia S, Zvelebil MJ, Stein R, Watton SJ, Layton MJ, Gout I, Ahmadi K, Downward J, Waterfield MD (Dec 1998). "Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity". The Journal of Biological Chemistry. 273 (49): 33082–90. doi:10.1074/jbc.273.49.33082. PMID 9830063.
^ ^a ^b "Entrez Gene: PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide".