Protein-coding gene in the species Homo sapiens
Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme , which in humans is encoded by the PIK3R3 gene .[ 5] [ 6]
Interactions
PIK3R3 has been shown to interact with Insulin-like growth factor 1 receptor ,[ 7] IRS1 [ 7] [ 8] Retinoblastoma protein .[ 9]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000117461 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028698 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Dey BR, Furlanetto RW, Nissley SP (May 1998). "Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor" . Gene . 209 (1– 2): 175– 83. doi :10.1016/S0378-1119(98)00045-6 PMID 9524259 . ^ "Entrez Gene: PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)" .^ a b Mothe, I; Delahaye L; Filloux C; Pons S; White M F; Van Obberghen E (Dec 1997). "Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins" . Mol. Endocrinol . 11 (13): 1911– 23. doi :10.1210/mend.11.13.0029 ISSN 0888-8809 . PMID 9415396 . ^ Xia, X; Serrero G (Aug 1999). "Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation" . Biochem. J . 341 (3): 831– 7. doi :10.1042/0264-6021:3410831 . ISSN 0264-6021 . PMC 1220424 PMID 10417350 . ^ Xia, Xianmin; Cheng Aiwu; Akinmade Damilola; Hamburger Anne W (Mar 2003). "The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest" . Mol. Cell. Biol . 23 (5): 1717– 25. doi :10.1128/MCB.23.5.1717-1725.2003 . ISSN 0270-7306 . PMC 151709 PMID 12588990 .
Further reading
Pons S, Asano T, Glasheen E, et al. (1995). "The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase" . Mol. Cell. Biol . 15 (8): 4453– 65. doi :10.1128/MCB.15.8.4453 . PMC 230685 PMID 7542745 . Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem . 236 (1): 107– 13. doi :10.1006/abio.1996.0138 . PMID 8619474 . Tuscano JM, Engel P, Tedder TF, et al. (1996). "Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22". Eur. J. Immunol . 26 (6): 1246– 52. doi :10.1002/eji.1830260610 . PMID 8647200 . S2CID 29471624 . Takahashi-Tezuka M, Hibi M, Fujitani Y, et al. (1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK" . Oncogene . 14 (19): 2273– 82. doi :10.1038/sj.onc.1201071 PMID 9178903 . Mothe I, Delahaye L, Filloux C, et al. (1998). "Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins" . Mol. Endocrinol . 11 (13): 1911– 23. doi :10.1210/mend.11.13.0029 PMID 9415396 . Xia X, Serrero G (1999). "Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation" . Biochem. J . 341 (3): 831– 7. doi :10.1042/0264-6021:3410831 . PMC 1220424 PMID 10417350 . Inukai K, Funaki M, Anai M, et al. (2001). "Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations" . FEBS Lett . 490 (1– 2): 32– 8. doi :10.1016/S0014-5793(01)02132-9 PMID 11172806 . Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2003). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun . 299 (5): 793– 800. doi :10.1016/S0006-291X(02)02718-3 . PMID 12470648 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Xia X, Cheng A, Akinmade D, Hamburger AW (2003). "The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest" . Mol. Cell. Biol . 23 (5): 1717– 25. doi :10.1128/MCB.23.5.1717-1725.2003 . PMC 151709 PMID 12588990 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40– 5. doi :10.1038/ng1285 PMID 14702039 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173– 8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Soroceanu L, Kharbanda S, Chen R, et al. (2007). "Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma" . Proc. Natl. Acad. Sci. U.S.A . 104 (9): 3466– 71. Bibcode :2007PNAS..104.3466S . doi :10.1073/pnas.0611271104 PMC 1802005 PMID 17360667 . Kallin A, Johannessen LE, Cani PD, et al. (2007). "SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma" . J. Lipid Res . 48 (7): 1628– 36. doi :10.1194/jlr.M700136-JLR200 PMID 17452746 .
