Phosphosulfolactate synthase

The enzyme phosphosulfolactate synthase (EC 4.4.1.19) catalyzes the reaction

(2R)-2-O-phospho-3-sulfolactate ${\displaystyle \rightleftharpoons }$ phosphoenolpyruvate + sulfite

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is (2R)-2-O-phospho-3-sulfolactate hydrogen-sulfite-lyase (phosphoenolpyruvate-forming). Other names in common use include (2R)-phospho-3-sulfolactate synthase, and (2R)-O-phospho-3-sulfolactate sulfo-lyase.

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1U83.

• Graham DE, Xu H, White RH (2002). "Identification of coenzyme M biosynthetic phosphosulfolactate synthase: a new family of sulfonate-biosynthesizing enzymes". J. Biol. Chem. 277 (16): 13421–9. doi:10.1074/jbc.M201011200. PMID 11830598.

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