Salicylate 1-monooxygenase

In enzymology, a salicylate 1-monooxygenase (EC 1.14.13.1) is an enzyme that catalyzes the chemical reaction

salicylate + NADH + 2 H⁺ + O₂ ${\displaystyle \rightleftharpoons }$ catechol + NAD⁺ + H₂O + CO₂

The 4 substrates of this enzyme are salicylate, NADH, H⁺, and O₂, whereas its 4 products are catechol, NAD⁺, H₂O, and CO₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. This enzyme participates in 3 metabolic pathways: 1- and 2-methylnaphthalene degradation, naphthalene and anthracene degradation, and fluorene degradation. It employs one cofactor, FAD.

The systematic name of this enzyme class is salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating).

Other names in common use include:

• salicylate hydroxylase,
• salicylate 1-hydroxylase,
• salicylate monooxygenase, and
• salicylate hydroxylase (decarboxylating)

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