Small Cajal body specific RNA 8

Small Cajal body specific RNA 8
Small Cajal body specific RNA 8
	Predicted secondary structure and sequence conservation of SCARNA8
Identifiers
Symbol	SCARNA8
Alt. Symbols	U92
Rfam	RF00286
Other data
RNA type	Gene; snRNA; snoRNA; scaRNA
Domain(s)	Eukaryota
GO	GO:0006396 GO:0015030 GO:0005730
SO	SO:0000275
PDB structures	PDBe

Small Cajal body specific RNA 8 (also known as SCARNA8 or U92) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U2 spliceosomal RNA.

scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.^[1]

U92 belong to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure, conserved H/ACA-box motifs and is found associated with GAR1.^[1] It is predicted to guide the pseudouridylation of residues U44 in U2 snRNA.^[1] This snoRNA is related to the mouse H/ACA box snoRNA MBI-57.^[2]