After receiving his doctorate, Wu joined the National Tsing Hua University faculty in 1987. Wu later became vice president of National Tsing Hua University. In this role, Wu attended the 2016 ceremony marking the establishment of an office for the China-funded Cross-Strait Tsinghua Research Institute at NTHU.[6][7][8] In 2017, Wu was one of eight candidates during the initial round of voting for the presidency of National Taiwan University.[9][10] After education minister Pan Wen-chung drew attention to a "flawed" selection process that saw the election of Kuan Chung-ming to the post,[11] Wu announced his intention to withdraw from further votes if interference took place in the selection of Kuan.[12]
In June 2024, Wu announced the government's proposal to extend the third phase of Taiwan's space development program.[20]
Wu undertook a trip to Silicon Valley in the United States in September 2024. The trip included a visit to Stanford University's Taiwan Science and Technology Hub and Nvidia.[21] In November 2024, Wu referenced in an interview that the Taiwanese government will spend NT$98 billion (about US$3 billion) over three years on artificial intelligence data centers and other upgrades, while working to strengthen cooperation with the United States' incoming Trump administration.[22]
In December 2024, Wu stated that the Taiwanese government was in talks with Amazon about collaborating for the company's Kuiper broadband satellites. According to Wu, bandwidth for the country's existing Eutelsat OneWeb satellite service was too small, and Taiwan had also considered working with other European and Canadian companies.[23] Wu also announced preparations for the "Chip Team Taiwan" initiative, which aimed to promote domestic production of drones, robotics, and other technologies and to reduce reliance on Chinese suppliers.[24]