Α-L-fucosidase

α-L-Fucosidase
crystal structure of Thermotoga maritima α-fucosidase
Identifiers
Symbol	α
Pfam	PF01120
Pfam clan	CL0058
InterPro	IPR000933
PROSITE	PDOC00324
SCOP2	1hl9 / SCOPe / SUPFAM
CAZy	GH29
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The enzyme α-L-fucosidase (EC 3.2.1.51) catalyzes the following chemical reaction: an α-L-fucoside + H₂O ${\displaystyle \rightleftharpoons }$ L-fucose + an alcohol

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is α-L-fucoside fucohydrolase. This enzyme is also called α-fucosidase. It participates in N-glycan degradation and glycan structure degradation.

Deficiency of this enzyme is called fucosidosis.

In CAZy, α-L-fucosidases are found in glycoside hydrolase family 29 and glycoside hydrolase family 95.

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1HL8, 1HL9, and 1ODU.

It was in a recent study by Endreffy, Bjørklund and collaborators (2017) found an association between the activity of α-L-fucosidase-1 (FUCA-1) and chronic autoimmune disorders in children.^[1] This should encourage further research on FUCA-1 as a marker of chronic inflammation and autoimmunity.

• 1,2-α-L-fucosidase
• 1,3-α-L-fucosidase
• 1,6-α-L-fucosidase
• FUCA1
• FUCA2

• Levvy GA, Mcallan A (August 1961). "Mammalian fucosidases. 2. α-L-Fucosidase". The Biochemical Journal. 80 (2): 435–9. doi:10.1042/bj0800435. PMC 1244021. PMID 13761578.
• Reglero A, Cabezas JA (July 1976). "Glycosidases of molluscs. Purification and properties of α-L-fucosidase from Chamelea gallina L". European Journal of Biochemistry. 66 (2): 379–87. doi:10.1111/j.1432-1033.1976.tb10527.x. PMID 7458.
• Tanaka K, Nakano T, Noguchi S, Pigman W (August 1968). "Purification of α-L-fucosidase of abalone livers". Archives of Biochemistry and Biophysics. 126 (2): 624–33. doi:10.1016/0003-9861(68)90449-9. PMID 5672520.

• CAZy family GH29
• CAZy family GH95