വിഷശാസ്ത്രത്തിൽ ഒരു വിഷത്തിന്റെയോ വിഷവസ്തുവിന്റെയോ റേഡിയേഷന്റെയോ മരണകാരണമാകാവുന്ന അളവിനെയാണ് മീഡിയൻ ലീതൽ ഡോസ് (the median lethal dose) , LD50 ( "lethal dose, 50%" - എന്നതിന്റെ ചുരുക്കെഴുത്ത്), LC50 (lethal concentration, 50% -എന്നതിന്റെ ചുരുക്കെഴുത്ത്) അല്ലെങ്കിൽ LCt50. പരീക്ഷണവിധേയമായ സഞ്ചയത്തിലെ എണ്ണത്തിന്റെ പകുതിയെ പരീക്ഷണത്തിനുതീരുമാനിക്കുന്ന സമയത്തിനുള്ളിൽ കൊല്ലാനുള്ള ഡോസ് ആണ് LD50. LD50 വിവരങ്ങൾ ഒരു പദാർത്ഥത്തിന്റെ മാരകഅളവിനെ കുറിക്കാൻ മിക്കവാറും ഉപയോഗിച്ചുവരുന്നു. LD50 - ന്റെ വില കുറവാണെങ്കിൽ വിഷശക്തി കൂടുതലായിരിക്കും.
Conventions
പരിമിതികൾ
ഉദാഹരണങ്ങൾ
Note: വസ്തുക്കളുടെ (പ്രത്യേകിച്ച് മരുന്നുകൾ) പരസ്പരം LD50 താരതമ്യം ചെയ്യുന്നത് പല കേസുകളിലും (ഭാഗികമായി) ഫലപ്രദമായ ഡോസിലെ വ്യത്യാസങ്ങൾ (ED50) വഴി തെറ്റിദ്ധരിപ്പിക്കുന്നതാണ്. അതിനാൽ, അത്തരം പദാർത്ഥങ്ങളെ ചികിത്സാ സൂചിക ഉപയോഗിച്ച് താരതമ്യം ചെയ്യുന്നത് കൂടുതൽ ഉപയോഗപ്രദമാണ്. ഇത് LD50 മുതൽ ED50 വരെയുള്ള അനുപാതമാണ്.
The following examples are listed in reference to LD50 values, in descending order, and accompanied by LC50 values, {bracketed}, when appropriate.
Substance
Animal, Route
LD50 {LC50 }
LD50 : g/kg {LC50 : g/L} standardized
Reference
Water
rat, oral
> 90,000 mg/kg
>90
[ 1]
Sucrose (table sugar)
rat, oral
29,700 mg/kg
29.7
[ 2]
Glucose (blood sugar)
rat, oral
25,800 mg/kg
25.8
[ 3]
Monosodium glutamate (MSG)
rat, oral
16,600 mg/kg
16.6
[ 4]
Stevioside (from stevia )
mice & rats, oral
>15,000 mg/kg
15
[ 5]
Vitamin C (ascorbic acid)
rat, oral
11,900 mg/kg
11.9
[ 6]
Lactose (milk sugar)
rat, oral
>10,000 mg/kg
10.0
[ 7]
Aspartame
mice, oral
>10,000 mg/kg
10.0
[ 8]
Urea
rat, oral
8,471 mg/kg
8.471
[ 9]
Cyanuric acid
rat, oral
7,700 mg/kg
7.7
[ 10]
Cadmium sulfide
rat, oral
7,080 mg/kg
7.08
[ 11]
Ethanol (Grain alcohol)
rat, oral
7,060 mg/kg
7.06
[ 12]
Sodium isopropyl methylphosphonic acid (IMPA, metabolite of sarin )
rat, oral
6,860 mg/kg
6.86
[ 13]
Melamine
rat, oral
6,000 mg/kg
6
[ 10]
Methanol
rat, oral
5,628 mg/kg
5.628
[ 14]
Taurine
rat, oral
>5,000 mg/kg
5.0
[ 15]
Melamine cyanurate
rat, oral
4,100 mg/kg
4.1
[ 10]
Fructose (fruit sugar)
rat, oral
4,000 mg/kg
4
[ 16]
Sodium molybdate
rat, oral
4,000 mg/kg
4
[ 17]
Sodium chloride (table salt)
rat, oral
3,000 mg/kg
3
[ 18]
Paracetamol (acetaminophen)
mouse, oral
338 mg/kg
0.338
[ 19]
Synthetic Delta-9-tetrahydrocannabinol (THC) + Polysorbate 80
rat, oral
1270 mg/kg
1.27
[ 20]
Cannabidiol (CBD)
rat, oral [അവലംബം ആവശ്യമാണ് ]
980 mg/kg
0.98
[ 21]
Metallic Arsenic
rat, oral
763 mg/kg
0.763
[ 22]
Ibuprofen
rat, oral
636 mg/kg
0.636
[ 23]
Formaldehyde
rat, oral
600–800 mg/kg
0.600
[ 24]
Alkyl dimethyl benzalkonium chloride (ADBAC)
rat, oral fish, immersion aquatic invertebrates, immersion
304.5 mg/kg {0.28 mg/L} {0.059 mg/L}
0.3045 {0.00028} {0.000059}
[ 25]
Coumarin (benzopyrone , from Cinnamomum aromaticum and other plants)
rat, oral
293 mg/kg
0.293
[ 26]
Psilocybin (from magic mushrooms )
mouse, oral
280 mg/kg
0.280
[ 27]
Hydrochloric acid
rat, oral
238–277 mg/kg
0.238
[ 28]
Ketamine
rat, intraperitoneal
229 mg/kg
0.229
[ 29]
Aspirin (acetylsalicylic acid)
rat, oral
200 mg/kg
0.2
[ 30]
Caffeine
rat, oral
192 mg/kg
0.192
[ 31]
Arsenic trisulfide
rat, oral
185–6,400 mg/kg
0.185–6.4
[ 32]
Sodium nitrite
rat, oral
180 mg/kg
0.18
[ 33]
Methylenedioxymethamphetamine (MDMA, ecstasy)
rat, oral
160 mg/kg
0.18
[ 34]
Uranyl acetate dihydrate
mouse, oral
136 mg/kg
0.136
[ 35]
Dichlorodiphenyltrichloroethane (DDT)
mouse, oral
135 mg/kg
0.135
[ 36]
Uranium
mice, oral
114 mg/kg (estimated)
0.114
[ 37]
Bisoprolol
mouse, oral
100 mg/kg
0.1
[ 38]
Cocaine
mouse, oral
96 mg/kg
0.096
[ 39]
Cobalt(II) chloride
rat, oral
80 mg/kg
0.08
[ 40]
Cadmium oxide
rat, oral
72 mg/kg
0.072
[ 41]
Thiopental sodium (used in lethal injection )
rat, oral
64 mg/kg
0.064
[ 42]
Methamphetamine
rat, intraperitoneal
57 mg/kg
0.057
[ 43]
Sodium fluoride
rat, oral
52 mg/kg
0.052
[ 44]
Pentaborane
human, oral
<50 mg/kg
<0.05
[ 45]
Capsaicin
mouse, oral
47.2 mg/kg
0.0472
[ 46]
Mercury(II) chloride
rat, dermal
41 mg/kg
0.041
[ 47]
Vitamin D3 (cholecalciferol)
rat, oral
37 mg/kg
0.037
[ 48]
Piperidine (from black pepper )
rat, oral
30 mg/kg
0.030
[ 49]
Heroin (diamorphine)
mouse, intravenous
21.8 mg/kg
0.0218
[ 50]
Lysergic acid diethylamide (LSD)
rat, intravenous
16.5 mg/kg
0.0165
[ 51]
Arsenic trioxide
rat, oral
14 mg/kg
0.014
[ 52]
Metallic Arsenic
rat, intraperitoneal
13 mg/kg
0.013
[ 53]
Nicotine
human, oral
mice, oral
6.5–13.0 mg/kg (estimated)
3.34 mg/kg
0.0065–0.013
0.0034
[ 54]
[ 55]
Sodium cyanide
rat, oral
6.4 mg/kg
0.0064
[ 56]
Hydrogen cyanide
mouse, oral
3.7 mg/kg
0.0037
[ 57]
Chlorotoxin (CTX, from scorpions )
mice
4.3 mg/kg
0.0043
[ 58]
White phosphorus
rat, oral
3.03 mg/kg
0.00303
[ 59]
Strychnine
human, oral
1–2 mg/kg (estimated)
0.001
[ 60]
Cantharidin (from blister beetles )
human, oral
500 µg/kg
0.0005
Aflatoxin B1 (from Aspergillus flavus mold)
rat, oral
480 µg/kg
0.00048
[ 61]
Plutonium
dog, intravenous
320 µg/kg
0.00032
[ 62]
Amatoxin (from Amanita phalloides mushrooms)
rat
300-700 µg/kg
0.0007
[ 63]
Tetrodotoxin (TTX, from blue-ringed octopus )
mice, oral
334 µg/kg
0.000334
[ 64]
Fentanyl
monkey
300 µg/kg
0.0003
[ 65]
Bufotoxin (from Bufo toads )
cat, intravenous
300 µg/kg
0.000300
[ 66]
Sarin
mouse, subcutaneous injection
172 µg/kg
0.000172
[ 67]
Robustoxin (from Sydney funnel-web spider )
mice
150 µg/kg
0.000150
[ 68]
VX
human, oral, inhalation, absorption through skin/eyes
140 µg/kg (estimated)
0.00014
[ 69]
Venom of the Brazilian wandering spider
rat, subcutaneous
134 µg/kg
0.000134
[ 70]
Venom of the Inland Taipan (Australian snake)
rat, subcutaneous
25 µg/kg
0.000025
[ 71]
Ricin (from castor oil plant )
rat, intraperitoneal rat, oral
22 μg/kg 20–30 mg/kg
0.000022 0.02
[ 72]
Carfentanil
human, oral
20 µg/kg
0.00002
[ 73]
2,3,7,8-Tetrachlorodibenzodioxin (TCDD, in Agent Orange )
rat, oral
20 µg/kg
0.00002
[ 74]
CrTX-A (from box jellyfish venom )
crayfish, intraperitoneal
5 µg/kg
0.000005
[ 75]
Latrotoxin (from widow spider venom )
mice
4.3 µg/kg
0.0000043
[ 76]
Batrachotoxin (from poison dart frog )
human, sub-cutaneous injection
2–7 µg/kg (estimated)
0.000002
[ 77]
Abrin (from rosary pea )
mice, intravenously
human, inhalation
human, oral
0.7 µg/kg
3.3 µg/kg
10–1000 µg/kg
0.0000007
0.0000033
0.00001–0.001
Maitotoxin (from ciguateric fish )
mouse, intraperitoneal
0.13 µg/kg
0.00000013
[ 78]
Polonium-210
human, inhalation
10 ng/kg (estimated)
0.00000001
[ 79]
Diphtheria toxin
mice
10 ng/kg
0.00000001
[ 80]
Shiga toxin (from dysentery )
mice
2 ng/kg
0.000000002
[ 80]
Tetanospasmin (tetanus toxin)
mice
2 ng/kg
0.000000002
[ 80]
Botulinum toxin (Botox)
human, oral, injection, inhalation
1 ng/kg (estimated)
0.000000001
[ 81]
Ionizing radiation
human, irradiation
5 Gy
[ 82]
മാരകമായ ഡോസുകളുടെ താരതമ്യം ലോഗരിതമിക് സ്കെയിൽ ലളിതമാക്കുന്നു
[ 83]
വിഷ സ്കെയിൽ
മൃഗാവകാശസംഘടനകളുടെ ഉൽക്കണ്ഠ
Animal-rights and animal-welfare groups, such as Animal Rights International,[ 84] have campaigned against LD50 testing on animals. Several countries, including the UK , have taken steps to ban the oral LD50 , and the Organisation for Economic Co-operation and Development (OECD) abolished the requirement for the oral test in 2001 (see Test Guideline 401, Trends in Pharmacological Sciences Vol 22, February 22, 2001).
ഇവയും കാണുക
Animal testing
Reed-Muench method
വിഷത്തെ അളക്കുന്ന മറ്റുരീതികൾ
ബന്ധപ്പെട്ട അളവുകൾ
TCID50 Tissue Culture Infective Dosage
EID50 Egg Infective Dosage
ELD50 Egg Lethal Dosage
Plaque forming units (pfu)
അവലംബം
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↑ Ketamine
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↑ DrugBank data for Cocaine
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↑ Thirty-Two Years of Measurable Change Archived 2007-02-11 at the Wayback Machine
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