GABA transporter tip 1

Familija trasportera rastvorka‎ 6 (neurotransmiterni transporter, GABA), član 1
Identifikatori
Simboli	SLC6A1; GABATHG; GABATR; GAT1
Vanjski ID	OMIM: 137165 MGI: 95627 HomoloGene: 2290 GeneCards: SLC6A1 Gene
Ontologija gena
Molekularna funkcija	• neurotransmiter: aktivnost natrijumskog simportera • gama-aminobutirna kiselina: aktivnost natrijumskog simportera
Celularna komponenta	• ćelijska membrana • integralno sa ćelijskom membranom • ćelijska površina • membrana
Biološki proces	• transport • sinaptička transmisija • sekrecija neurotransmitera • učenje
Pregled RNK izražavanja
	podaci
Ortolozi

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GABA transporter 1 (GAT-1, natrijum- i hlorid-zavisni GABA transporter 1) je protein koji je kod ljudi kodiran SLC6A1 genom.^[1]^[2]

Funkcija

GAT-1 je transporter gama-aminobuterne kiseline (GABA), koji uklanja GABA iz sinaptičkog rascepat.^[3]

Interakcije

SLC6A1 formira interakcije sa STX1A.^[4]^[5]^[6]

Reference

↑ Huang F, Shi LJ, Heng HH, Fei J, Guo LH (February 1996). „Assignment of the human GABA transporter gene (GABATHG) locus to chromosome 3p24-p25”. Genomics 29 (1): 302–4. DOI:10.1006/geno.1995.1253. PMID 8530094.
↑ „Entrez Gene: SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1”.
↑ Hirunsatit R, George ED, Lipska BK, Elwafi HM, Sander L, Yrigollen CM, Gelernter J, Grigorenko EL, Lappalainen J, Mane S, Nairn AC, Kleinman JE, Simen AA (January 2009). „Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity”. Pharmacogenet. Genomics 19 (1): 53–65. DOI:10.1097/FPC.0b013e328318b21a. PMID 19077666.
↑ Beckman, M L; Bernstein E M, Quick M W (August 1998). „Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A”. J. Neurosci. (UNITED STATES) 18 (16): 6103–12. ISSN 0270-6474. PMID 9698305.
↑ Quick, Michael W (April 2002). „Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner”. Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (8): 5686–91. DOI:10.1073/pnas.082712899. ISSN 0027-8424. PMC 122832. PMID 11960023.
↑ Deken, S L; Beckman M L, Boos L, Quick M W (October 2000). „Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A”. Nat. Neurosci. (UNITED STATES) 3 (10): 998–1003. DOI:10.1038/79939. ISSN 1097-6256. PMID 11017172.

Literatura

Nelson H, Mandiyan S, Nelson N (1990). „Cloning of the human brain GABA transporter.”. FEBS Lett. 269 (1): 181–4. DOI:10.1016/0014-5793(90)81149-I. PMID 2387399.
Bennett ER, Kanner BI (1997). „The membrane topology of GAT-1, a (Na+ + Cl-)-coupled gamma-aminobutyric acid transporter from rat brain.”. J. Biol. Chem. 272 (2): 1203–10. DOI:10.1074/jbc.272.2.1203. PMID 8995422.
Bismuth Y, Kavanaugh MP, Kanner BI (1997). „Tyrosine 140 of the gamma-aminobutyric acid transporter GAT-1 plays a critical role in neurotransmitter recognition.”. J. Biol. Chem. 272 (26): 16096–102. DOI:10.1074/jbc.272.26.16096. PMID 9195904.
DeFelipe J, González-Albo MC (1998). „Chandelier cell axons are immunoreactive for GAT-1 in the human neocortex.”. Neuroreport 9 (3): 467–70. DOI:10.1097/00001756-199802160-00020. PMID 9512391.
Conti F, Melone M, De Biasi S, et al. (1998). „Neuronal and glial localization of GAT-1, a high-affinity gamma-aminobutyric acid plasma membrane transporter, in human cerebral cortex: with a note on its distribution in monkey cortex.”. J. Comp. Neurol. 396 (1): 51–63. DOI:10.1002/(SICI)1096-9861(19980622)396:1<51::AID-CNE5>3.0.CO;2-H. PMID 9623887.
Beckman ML, Bernstein EM, Quick MW (1998). „Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A.”. J. Neurosci. 18 (16): 6103–12. PMID 9698305.
Augood SJ, Waldvogel HJ, Münkle MC, et al. (1999). „Localization of calcium-binding proteins and GABA transporter (GAT-1) messenger RNA in the human subthalamic nucleus.”. Neuroscience 88 (2): 521–34. DOI:10.1016/S0306-4522(98)00226-7. PMID 10197772.
Ong WY, Yeo TT, Balcar VJ, Garey LJ (2000). „A light and electron microscopic study of GAT-1-positive cells in the cerebral cortex of man and monkey.”. J. Neurocytol. 27 (10): 719–30. DOI:10.1023/A:1006946717065. PMID 10640187.
Deken SL, Beckman ML, Boos L, Quick MW (2000). „Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A.”. Nat. Neurosci. 3 (10): 998–1003. DOI:10.1038/79939. PMID 11017172.
Whitworth TL, Quick MW (2001). „Substrate-induced regulation of gamma-aminobutyric acid transporter trafficking requires tyrosine phosphorylation.”. J. Biol. Chem. 276 (46): 42932–7. DOI:10.1074/jbc.M107638200. PMID 11555659.
Hachiya Y, Takashima S (2002). „Development of GABAergic neurons and their transporter in human temporal cortex.”. Pediatr. Neurol. 25 (5): 390–6. DOI:10.1016/S0887-8994(01)00348-4. PMID 11744314.
Quick MW (2002). „Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner.”. Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5686–91. DOI:10.1073/pnas.082712899. PMC 122832. PMID 11960023.
Kanner BI (2003). „Transmembrane domain I of the gamma-aminobutyric acid transporter GAT-1 plays a crucial role in the transition between cation leak and transport modes.”. J. Biol. Chem. 278 (6): 3705–12. DOI:10.1074/jbc.M210525200. PMID 12446715.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zomot E, Kanner BI (2003). „The interaction of the gamma-aminobutyric acid transporter GAT-1 with the neurotransmitter is selectively impaired by sulfhydryl modification of a conformationally sensitive cysteine residue engineered into extracellular loop IV.”. J. Biol. Chem. 278 (44): 42950–8. DOI:10.1074/jbc.M209307200. PMID 12925537.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
Zhou Y, Bennett ER, Kanner BI (2004). „The aqueous accessibility in the external half of transmembrane domain I of the GABA transporter GAT-1 Is modulated by its ligands.”. J. Biol. Chem. 279 (14): 13800–8. DOI:10.1074/jbc.M311579200. PMID 14744863.
Hu JH, Ma YH, Jiang J, et al. (2004). „Cognitive impairment in mice over-expressing gamma-aminobutyric acid transporter 1 (GAT1).”. Neuroreport 15 (1): 9–12. DOI:10.1097/00001756-200401190-00003. PMID 15106822.
Korkhov VM, Farhan H, Freissmuth M, Sitte HH (2005). „Oligomerization of the {gammaaminobutyric acid transporter-1 is driven by an interplay of polar and hydrophobic interactions in transmembrane helix II.”. J. Biol. Chem. 279 (53): 55728–36. DOI:10.1074/jbc.M409449200. PMID 15496410.

Povezano

Familija trasportera rastvorka

[pmid8530094-1] Huang F, Shi LJ, Heng HH, Fei J, Guo LH (February 1996). „Assignment of the human GABA transporter gene (GABATHG) locus to chromosome 3p24-p25”. Genomics 29 (1): 302–4. DOI:10.1006/geno.1995.1253. PMID 8530094.

[entrez-2] „Entrez Gene: SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1”.

[pmid19077666-3] Hirunsatit R, George ED, Lipska BK, Elwafi HM, Sander L, Yrigollen CM, Gelernter J, Grigorenko EL, Lappalainen J, Mane S, Nairn AC, Kleinman JE, Simen AA (January 2009). „Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity”. Pharmacogenet. Genomics 19 (1): 53–65. DOI:10.1097/FPC.0b013e328318b21a. PMID 19077666.

[pmid9698305-4] Beckman, M L; Bernstein E M, Quick M W (August 1998). „Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A”. J. Neurosci. (UNITED STATES) 18 (16): 6103–12. ISSN 0270-6474. PMID 9698305.

[pmid11960023-5] Quick, Michael W (April 2002). „Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner”. Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (8): 5686–91. DOI:10.1073/pnas.082712899. ISSN 0027-8424. PMC 122832. PMID 11960023.

[pmid11017172-6] Deken, S L; Beckman M L, Boos L, Quick M W (October 2000). „Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A”. Nat. Neurosci. (UNITED STATES) 3 (10): 998–1003. DOI:10.1038/79939. ISSN 1097-6256. PMID 11017172.

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