Akrozin

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Akrozin
Akrozin
Identifikatori
EC broj	3.4.21.10
CAS broj	9068-57-9
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Akrozin (EC 3.4.21.10, akrozomalna proteinaza, akrozonaza, alfa-akrozin, beta-akrosin, upsilon-akrosin, akrozinska amidaza) je enzim.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Selektivno odvajanje: Arg-, Lys-

Ovaj enzim je izolovan iz spermatozoida.

Reference

^ Müller-Esterl, W. & Fritz, H. (1981). „Sperm acrosin”. Methods Enzymol. 80: 621—632. PMID 7043204.
^ Skoog, M.T., Mehdi, S., Wiseman, J.S. and Bey, P. The specificity of two proteinases that cleave adjacent to arginine, C (1989). „1 esterase and acrosin, for peptide p-nitroanilide substrates”. Biochim. Biophys. Acta. 996: 89—94. PMID 2500154.
^ Keime, S., Adham, I.M. and Engel, W. (1990). „Nucleotide sequence and exon-intron organisation of the human proacrosin gene”. Eur. J. Biochem. 190: 195—200. PMID 2114285.

Literatura

Elce JS, McIntyre EJ (1982). „Purification of bovine and human acrosin”. Can. J. Biochem. 60 (1): 8—14. PMID 6802470. doi:10.1139/o82-002.
X, Zheng; Geiger M; Ecke S (1994). „Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa”. Am. J. Physiol. 267 (2 Pt 1): C466—72. PMID 7521127.
K, Kimura; Wakamatsu A; Suzuki Y (2006). „Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes”. Genome Res. 16 (1): 55—65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
Klemm U, Müller-Esterl W, Engel W (1991). „Acrosin, the peculiar sperm-specific serine protease”. Hum. Genet. 87 (6): 635—41. PMID 1937464.
Kim J, Bhinge AA, Morgan XC, Iyer VR (2005). „Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment”. Nat. Methods. 2 (1): 47—53. PMID 15782160. doi:10.1038/nmeth726.
Moreno RD, Hoshi M, Barros C (1999). „Functional interactions between sulphated polysaccharides and proacrosin: implications in sperm binding and digestion of zona pellucida”. Zygote. 7 (2): 105—11. PMID 10418103. doi:10.1017/S0967199499000453.
RZ, Liu; Lu YL; Xu ZG (2003). „[The effect of semen antisperm antibody on human sperm acrosin activity]”. Zhonghua Nan Ke Xue. 9 (4): 252—3. PMID 12931362.
Steven FS, Griffin MM, Chantler EN (1982). „Inhibition of human and bovine sperm acrosin by divalent metal ions. Possible role of zinc as a regulator of acrosin activity”. Int. J. Androl. 5 (4): 401—12. PMID 6815104. doi:10.1111/j.1365-2605.1982.tb00270.x.
MarÃ SI, Rawe V, Biancotti JC, (2003). „Biochemical and molecular studies of the proacrosin/acrosin system in patients with unexplained infertility”. Fertil. Steril. 79 Suppl 3: 1676—9. PMID 12801583. soft hyphen character у |author= на позицији 5 (помоћ)
Glogowski J, Demianowicz W, Piros B, Ciereszko A (1998). „Determination of acrosin activity of boar spermatozoa by the clinical method: optimization of the assay and changes during short-term storage of semen”. Theriogenology. 50 (6): 861—72. PMID 10734459. doi:10.1016/S0093-691X(98)00191-5.
Furlong LI, Veaute C, Vazquez-Levin MH (2005). „Binding of recombinant human proacrosin/acrosin to zona pellucida glycoproteins. II. Participation of mannose residues in the interaction”. Fertil. Steril. 83 (6): 1791—6. PMID 15950652. doi:10.1016/j.fertnstert.2004.12.043.
Furlong LI, Harris JD, Vazquez-Levin MH (2005). „Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC”. Fertil. Steril. 83 (6): 1780—90. PMID 15950651. doi:10.1016/j.fertnstert.2004.12.042.
Hartley JL, Temple GF, Brasch MA (2000). „DNA Cloning Using In Vitro Site-Specific Recombination”. Genome Res. 10 (11): 1788—95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
JE, Collins; Wright CL; Edwards CA (2004). „A genome annotation-driven approach to cloning the human ORFeome”. Genome Biol. 5 (10): R84. PMC 545604 . PMID 15461802. doi:10.1186/gb-2004-5-10-r84.
C, Dubé; Leclerc P; Baba T (2005). „The proacrosin binding protein, sp32, is tyrosine phosphorylated during capacitation of pig sperm”. J. Androl. 26 (4): 519—28. PMID 15955892. doi:10.2164/jandrol.04163.
RL, Strausberg; Feingold EA; Grouse LH (2002). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
A, Zahn; Furlong LI; Biancotti JC (2002). „Evaluation of the proacrosin/acrosin system and its mechanism of activation in human sperm extracts”. J. Reprod. Immunol. 54 (1–2): 43—63. PMID 11839395. doi:10.1016/S0165-0378(01)00080-8.
Howes E, Pascall JC, Engel W, Jones R (2001). „Interactions between mouse ZP2 glycoprotein and proacrosin; a mechanism for secondary binding of sperm to the zona pellucida during fertilization”. J. Cell. Sci. 114 (Pt 22): 4127—36. PMID 11739644.
Yudin AI, Vandevoort CA, Li MW, Overstreet JW (1999). „PH-20 but not acrosin is involved in sperm penetration of the macaque zona pellucida”. Mol. Reprod. Dev. 53 (3): 350—62. PMID 10369396. doi:10.1002/(SICI)1098-2795(199907)53:3<350::AID-MRD11>3.0.CO;2-9.
Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Acrosin на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Müller-Esterl, W. & Fritz, H. (1981). „Sperm acrosin”. Methods Enzymol. 80: 621—632. PMID 7043204.

[2] Skoog, M.T., Mehdi, S., Wiseman, J.S. and Bey, P. The specificity of two proteinases that cleave adjacent to arginine, C (1989). „1 esterase and acrosin, for peptide p-nitroanilide substrates”. Biochim. Biophys. Acta. 996: 89—94. PMID 2500154.

[3] Keime, S., Adham, I.M. and Engel, W. (1990). „Nucleotide sequence and exon-intron organisation of the human proacrosin gene”. Eur. J. Biochem. 190: 195—200. PMID 2114285.

[1]

[2]

[3]

Akrozin

Reference

Literatura

Spoljašnje veze

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