特立氟胺 特立氟胺 臨床資料 商品名（英语：Drug nomenclature） Aubagio 其他名稱 A77 1726 AHFS/Drugs.com Monograph MedlinePlus a613010 核准狀況 美 DailyMed: Teriflunomide 懷孕分級 澳: X (高风险) [1] Contraindicated[1] 给药途径 口服给药 ATC碼 L04AK02 (WHO) 法律規範狀態 法律規範 澳：限医生处方（S4） 歐：Rx-only[3] 美：处方药（℞-only）[2] 藥物動力學數據 血漿蛋白結合率 >99.3% 生物半衰期 2 weeks 排泄途徑 Bile duct/fecal, kidney 识别信息 IUPAC命名法 (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide CAS号 163451-81-8  N PubChem CID 54684141 IUPHAR/BPS 6844 DrugBank DB08880 Y ChemSpider 16737143 Y UNII 1C058IKG3B KEGG D10172 N ChEBI CHEBI:68540 N ChEMBL ChEMBL973 Y CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA) DTXSID80893457 ECHA InfoCard 100.170.077 化学信息 化学式 C12H9F3N2O2 摩尔质量 270.21 g·mol−1 3D模型（JSmol（英语：JSmol）） 交互式图像 SMILES O=C(Nc1ccc(cc1)C(F)(F)F)C(/C#N)=C(/C)O InChI InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7- Y Key:UTNUDOFZCWSZMS-YFHOEESVSA-N Y 特立氟胺（英語：Teriflunomide，商品名：Aubagio）是一种含氮有机氟化合物，分子式C 12H 9F 3N 2O 2，能作为多发性硬化症药物[5]，也是来氟米特的活性代謝產物[6]。 参考文献 ^ 1.0 1.1 Teriflunomide (Aubagio) Use During Pregnancy. Drugs.com. 11 September 2019 [2 March 2020].  ^ Aubagio- teriflunomide tablet, film coated. DailyMed. 21 November 2023 [13 June 2024].  ^ Aubagio EPAR. European Medicines Agency (EMA). 26 August 2013 [13 June 2024].  ^ Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 31 March 2023 (4 April 2023) [16 August 2023]. （原始内容存档于3 August 2023） （巴西葡萄牙语）.  请检查|publication-date=中的日期值 (帮助) ^ Clinical trial number NCT00134563 for "Phase III Study of Teriflunomide in Reducing the Frequency of Relapses and Accumulation of Disability in Patients With Multiple Sclerosis (TEMSO)" at ClinicalTrials.gov ^ Magne D, Mézin F, Palmer G, Guerne PA. The active metabolite of leflunomide, A77 1726, increases proliferation of human synovial fibroblasts in presence of IL-1beta and TNF-alpha. Inflammation Research. November 2006, 55 (11): 469–75. PMID 17122964. S2CID 47034503. doi:10.1007/s00011-006-5196-x.  外部链接

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