芬太尼类物质 芬太尼类物质（fentanyl analogs，fentalogs[1][2]）是指芬太尼的类似物，满足以下条件之一： （1）丙酰基（用红色标注）被其他酰基替代； （2）与氮原子直接相连的苯基（用蓝色标注）被任何取代或未取代的单环芳香基团替代； （3）哌啶环（用橙色标注）上存在烷基、烯基、烷氧基、酯基、醚基、羟基、卤素、卤代烷基、氨基及硝基等取代基； （4）苯乙基（用绿色标注）被使用除氢原子外的任意基团替代[3]。 列表 满足一个条件 化学结构 常用名 化学名 CAS号 满足条件 Thiophenylfentanyl (Thiofuranylfentanyl)[4] N-Phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]thiophene-2-carboxamide 2306823-38-9 （1） 3-呋喃基芬太尼 (3FUF) N-Phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]furan-3-carboxamide 101343-82-2 （1） 2-呋喃基芬太尼 (Fu-F, FUF) N-Phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]furan-2-carboxamide 101345-66-8 （1） 四氢呋喃芬太尼 N-Phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]oxolane-2-carboxamide 2142571-01-3 （1） 环戊基芬太尼 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]cyclopentanecarboxamide 2088918-01-6 （1） 环丁基芬太尼[5] N-[1-(2-Phenylethyl)piperidin-4-yl]-N-phenylcyclobutanecarboxamide 2306827-55-2 （1） 环丙基芬太尼 N-[1-(2-Phenylethyl)piperidin-4-yl]-N-phenylcyclopropanecarboxamide 1169-68-2 （1） 四甲基环丙基芬太尼[6] 2,2,3,3-Tetramethyl-N-(1-phenethylpiperidin-4-yl)-N-phenylcyclopropane-1-carboxamide 2309383-11-5 （1） 巴豆酰芬太尼 N-Phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]-2-butenamide 760930-59-4 （1） 二甲烯丙酰芬太尼[7] N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]-3-methylbut-2-enamide 2630378-28-6 （1） 丙烯酰芬太尼 N-Phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]prop-2-enamide 82003-75-6 （1） 甲氧乙酰基芬太尼 (MAF) 2-Methoxy-N-(1-phenethylpiperidin-4-yl)-N-phenylacetamide 101345-67-9 （1） 乙氧乙酰基芬太尼 2-ethoxy-N-(1-phenethylpiperidin-4-yl)-N-phenylacetamide （1） 乙酰芬太尼 N-(1-Phenethylpiperidin-4-yl)-N-phenylacetamide 3258-84-2 （1） 异丁酰芬太尼 2-methyl-N-phenyl-N-[1-(1-phenylpropan-2-yl)piperidin-4-yl]propanamide 119618-70-1 （1） 丁酰芬太尼 (Bu-F, BUF) N-(1-(2-Phenylethyl)-4-piperidinyl)-N-phenylbutyramide 1169-70-6 （1） 戊酰芬太尼 (VF) N-(1-(2-Phenylethyl)-4-piperidinyl)-N-phenylpentylamide 122882-90-0 （1） Fentanyl carbamate ethyl N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]carbamate 1465-20-9 （1） 脲芬太尼 Ureafentanyl N,N-dimethyl-N'-phenyl-N'-[1-(2-phenylethyl)-4-piperidinyl]-urea 1443-50-1 （1） Benzoylfentanyl N-(1-Phenethylpiperidin-4-yl)-N-phenylbenzamide 2309383-15-9 （1） 3-Phenylpropanoylfentanyl[8] N-Phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]-3-phenylpropanamide 79279-02-0 （1） Benzodioxolefentanyl[9] N-Phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]-2H-1,3-benzodioxole-5-carboxamide 2306823-01-6 （1） Paramethylfentanyl (p-MF) N-(4-methylphenyl)-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide 1838-67-1 （2） 4-Fluorofentanyl N-(4-fluorophenyl)-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide 90736-23-5 （2） meta-fluorofentanyl N-(3-Fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide 90736-22-4 （2） 3-Methylfentanyl (3-MF) N-(3-methyl-1-phenethyl-4-piperidyl)-N-phenyl-propanamide 42045-86-3 （3） 2,5-Dimethylfentanyl N-[2,5-Dimethyl-1-(2-phenylethyl)piperidin-4-yl]-N-phenylpropanamide 42045-97-6 （3） 3-Allylfentanyl N-[(3S,4R)-1-Phenethyl-3-prop-2-enylpiperidin-4-yl]-N-phenylpropanamide 82208-84-2 （3） 3-Fluorofentanyl (NFEPP) N-(3-Fluoro-1-phenethylpiperidin-4-yl)-N-phenylpropionamide 1422952-84-8 （3） Tetramethylfentanyl N-(2,2,6,6-tetramethyl-1-phenethyl-4-piperidyl)-N-phenyl-propanamide （3） 4-Phenylfentanyl N-Phenyl-N-[4-phenyl-1-(2-phenylethyl)piperidin-4-yl]propanamide 120448-97-7 （3） 卡芬太尼（英语：carfentanil） Methyl 1-(2-phenylethyl)-4-[phenyl(propanoyl)amino]piperidine-4-carboxylate 59708-52-0 （3） 乙基卡芬太尼 Ethyl 1-(2-phenylethyl)-4-[phenyl(propanoyl)amino]piperidine-4-carboxylate （3） MP102 N-cycloheptyl-1-(2-phenylethyl)-4-(N-propanoylanilino)piperidine-4-carboxamide （3） MP135[10] N-[4[2-(3-fluorophenyl)ethyl]carboxamido1-(2-phenylethyl)piperidin-4-yl]-N-benzylpropanamide 2677687-49-7 （3） Thenylfentanyl N-phenyl-N-{[1-(thiophen-2-ylmethyl)piperidin-4-yl]methyl}propanamide 117332-93-1 （4） 苄基芬太尼 N-(1-Benzylpiperidin-4-yl)-N-phenylpropanamide 1474-02-8 （4） 高芬太尼 (N-phenylpropylnorfentanyl) [11] N-phenyl-N-[1-(3-phenylpropyl)piperidin-4-yl]propanamide 59708-54-2 （4） R-4173[12] N-phenyl-N-{1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl}propanamide 2413-90-3 （4） 4"-Fluorofentanyl N-[1-[2-(4-Fluorophenyl)ethyl]-4-piperidinyl]-N-phenylpropanamide 2748343-99-7 （4） 阿法甲基芬太尼 (AMF) N-phenyl-N-[1-(1-phenylpropan-2-yl)-4-piperidyl]propanamide 79704-88-4 （4） 阿法甲基硫代芬太尼 N-Phenyl-N-[1-(1-thiophen-2-ylpropan-2-yl)-4-piperidyl]propanamide 103963-66-2 （4） α-Methyl-β-hydroxyfentanyl[13] N-[1-(1-hydroxy-1-phenylpropan-2-yl)piperidin-4-yl]-N-phenylpropanamide （4） β-Methylfentanyl N-Phenyl-N-[1-(2-phenylpropyl)piperidin-4-yl]propanamide 79146-56-8 （4） β-Hydroxyfentanyl N-[1-(2-Hydroxy-2-phenylethyl)piperidin-4-yl]-N-phenylpropanamide 78995-10-5 （4） β-Hydroxythiofentanyl N1-[2-Hydroxy-2-(thiophen-2-yl)ethyl]piperidin-4-ylN-phenylpropanamide 1474-34-6 （4） 2-Benzofuranylethyl-alpha-methylfentanyl N-(1-[1-(1-Benzofuran-2-yl)-2-propanyl]-4-piperidinyl)-N-phenylpropanamide （4） trans-phenylcyclopropyl-norfentanyl 1-(trans-2-Phenylcyclopropyl)-4-(N-propionylanilino)piperidine. 102504-49-4 （4） Furanylethylfentanyl (FUEF) N-[1-[2-(2-furanyl)ethyl]-4-piperidinyl]-N-phenyl-propanamide 802544-02-1 （4） Pyridylfentany[14] N-phenyl-N-[1-(2-pyridin-4-ylethyl)piperidin-4-yl]propanamide 1443-41-0 （4） N-(MDA)-fentanyl[15] N-(1-(1-(benzo[d][1,3]dioxol-5-yl)propan-2-yl)piperidin-4-yl)-N-phenylpropionamide （4） N-(2C-B)-fentanyl N-(1-(2-(2,5-dimethoxy-4-bromophenyl)ethyl)piperidin-4-yl)-N-phenylpropionamide （4） 满足多个条件 化学结构 常用名 化学名 CAS号 满足条件 2-Methylmethoxyacetylfentanyl N-(2-Methylphenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-2-methoxyacetamide 2748485-22-3 （1）（2） 2-Fluoroacrylfentanyl N-(2-Fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-propen-2-amide 2309383-09-1 （1）（2） 2-Fluorobutyrfentanyl (o-FBF) N-(2-Fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-butanamide 2163847-76-3 （1）（2） 2-Fluoroisobutyrfentanyl (o-FIBF) N-(2-Fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-2-methylpropanamide 2351142-33-9 （1）（2） 2-Methylacetylfentanyl (o-MAF) N-(2-Methylphenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-acetamide 90736-11-1 （1）（2） 2,2'-Difluorofentanyl N-(2-Fluorophenyl)-N-[1-(2-[2-fluorophenyl]ethyl)-4-piperidinyl]-propanamide 2748343-87-3 （2）（4） 3-Methylbutyrfentanyl N-[3-Methyl-1-(2-phenylethyl)piperidin-4-yl]-N-phenylbutanamide 97605-09-9 （1）（3） 3-Methylcrotonylfentanyl N-Phenyl-N-[1-(2-phenylethyl)-4-(3-methylpiperidin-1-yl)]-2-butenamide 144480-29-5 （1）（3） p-Methylcrotonylfentanyl N-(4-methylphenyl)-N-[1-(2-phenylethyl)-4-(piperidin-1-yl)]-2-butenamide 2734344-10-4 （1）（2） 3-Methylfuranylfentanyl[16] (3MFUF, TMFUF) N-Phenyl-N-[3-methyl-1-(2-phenylethyl)piperidin-4-yl]furan-2-carboxamide （1）（3） 3-甲基硫代芬太尼 N3-Methyl-1-[2-(2-thienyl)ethyl]piperidin-4-ylN-phenylpropanamide 86052-04-2 （3）（4） 4-Fluorobutyrfentanyl (4-FBF) N-(4-Fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-butanamide 244195-31-1 4-Chloroisobutyrylfentanyl (4-CIBF) [17] 2-Methyl-N-(4-chlorophenyl)-N-[1-(1-phenylpropan-2-yl)piperidin-4-yl]propanamide 244195-34-4 4-Fluoroisobutyrfentanyl (4-FIBF) N-(4-Fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-isobutanamide 244195-32-2 para-fluorofuranylfentanyl[18] (p-F-Fu-F) N-(1-phenethylpiperidin-4-yl)-N-(4-fluorophenyl)furan-2-carboxamide 1802489-71-9 para-chlorofuranylfentanyl (p-Cl-Fu-F) N-(1-phenethylpiperidin-4-yl)-N-(4-chlorophenyl)furan-2-carboxamide ortho-methylfuranylfentanyl (o-Me-Fu-F) N-(1-phenethylpiperidin-4-yl)-N-(o-tolyl)furan-2-carboxamide 2309383-07-9 ortho-methoxyfuranylfentanyl (o-MeO-Fu-F) N-(1-phenethylpiperidin-4-yl)-N-(2-methoxyphenyl)furan-2-carboxamide 101343-50-4 ortho-isopropylfuranylfentanyl (o-iPr-Fu-F) N-(1-phenethylpiperidin-4-yl)-N-(2-isopropylphenyl)furan-2-carboxamide 4-Methoxybutyrfentanyl N-(4-Methoxyphenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-butanamide 2088842-68-4 para-Hydroxy‐butyrylfentanyl [19] N-(4-hydroxyphenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-butanamide 4"-Fluoro-o-fluoro-3-methylfentanyl N-(2-fluorophenyl)-N-[1-[2-(4-fluorophenyl)ethyl]-3-methylpiperidin-4-yl]propanamide 4-Methyl-methoxyacetylfentanyl (4-Me-MAF) N-(4-Methylphenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-2-methoxyacetamide 4-Methylphenethylacetylfentanyl[20] N-[1-[2-(4-Methylphenyl)ethyl]-4-piperidinyl]-N-phenylacetamide 1071703-95-1 α-Methylacetylfentanyl N-Phenyl-N-[1-(1-phenylpropan-2-yl)-4-piperidyl]acetamide 101860-00-8 α-Methylbutyrfentanyl N-phenyl-N-[1-(1-phenylpropan-2-yl)-4-piperidyl]butanamide 244195-36-6 阿芬太尼（英语：alfentanil） N1-[2-(4-ethyl-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl)ethyl]-4-(methoxymethyl)piperidin-4-ylN-phenylpropanamide 71195-58-9 BDBM50223545 (Berger Fentanyl) [21] [22] 1-[2-(2-phenylethyl)-3,4,4a,9b-tetrahydro-1H-pyrido[4,3-b]indol-5-yl]propan-1-one β-Hydroxy-4-methylfentanyl N-[1-(2-hydroxy-2-phenylethyl)-4-methylpiperidin-4-yl]-N-phenylpropanamide Brorphine[23] 11-[1-(4-bromophenyl)ethyl]piperidin-4-yl1,3-dihydro-2H-benzimidazol-2-one 2244737-98-0 Brifentanyl N-[(3R,4S)-1-[2-(4-Ethyl-5-oxotetrazol-1-yl)ethyl] -3-methylpiperidin-4-yl]-N-(2-fluorophenyl)-2-methoxyacetamide 101345-71-5 苄基卡芬太尼 Methyl 1-benzyl-4-[phenyl(propanoyl)amino]piperidine-4-carboxylate 61085-72-1 EAZ-91-05, Psicofentanil (quinuclidin-3-yl) 4-[phenyl(propanoyl)amino]-1-[2-(indol-3-yl)ethyl]piperidine-4-carboxylate 异芬太尼 N-(1-Benzyl-3-methylpiperidin-4-yl)-N-phenylpropanamide 79278-40-3 Fentanyl azepane N-phenyl-N-[1-(2-phenylethyl)azepan-4-yl]propanamide Furanylbenzylfentanyl N-Phenyl-N-(1-benzylpiperidin-4-yl)furan-2-carboxamide 497240-21-8 Fentanyl 4-methylene analogue (WO 2007/093603) N-phenyl-N-{[1-(2-phenylethyl)piperidin-4-yl]methyl}propanamide 947139-57-3 Indolylethylfentanyl N-(1-[2-(1H-indol-3-yl)ethyl]-4-piperidinyl)-N-phenyl-propanamide 58399-46-5 IQMF-4[24] N-[1-(2-Phenylethyl)piperidin-4-yl]-N-(1-phenylpyrazol-3-yl)prop-2-enamide 497100-48-8 Lofentanyl methyl (3S,4R)-3-methyl-1-(2-phenylethyl)-4-[phenyl(propionyl)amino]piperidine-4-carboxylate 61380-40-3 N-Methylnorcarfentanyl methyl 1-methyl-4-(N-phenylpropanamido)piperidine-4-carboxylate 59708-50-8 Meta-fluoro-methoxyacetylfentanyl 2-Methoxy-N-(1-phenethylpiperidin-4-yl)-N-(3-fluorophenyl)acetamide 2306825-32-9 4-(Methylthiazolyl)-pyrazolylethylfentanyl[25] 1-[2-(1H-pyrazol-1-yl)ethyl]-4-(4-methylthiazol-2-yl)-4-(N-phenylpropionamido)piperidine 120070-51-1 Mirfentanyl N-[1-(2-Phenylethyl)piperidin-4-yl]-N-pyrazin-2-yl-2-furamide 117523-47-4 奥芬太尼 N-(2-Fluorophenyl)-2-methoxy-N-[1-(2-phenylethyl)piperidin-4-yl]acetamide 101343-69-5 羟甲芬太尼 N-[1-(2-hydroxy-2-phenylethyl)-3-methylpiperidin-4-yl]-N-phenylpropanamide 78995-14-9 羟甲卡芬太尼 methyl 1-(2-hydroxy-2-phenylethyl)-3-methyl-4-(N-propanoylanilino)piperidine-4-carboxylate 4"-Fluoroohmefentanyl methyl 1-[2-hydroxy-2-(4-fluorophenyl)ethyl]-3-methyl-4-(N-propanoylanilino)piperidine-4-carboxylate 4"-Fluoro-ohlofentanyl methyl 1‐[2‐(4‐fluorophenyl)‐2‐hydroxyethyl]‐3‐methyl‐4‐(N‐phenylpropanamido)piperidine‐4‐carboxylate Orthofluorofentanyl N-(2-Fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide 910616-29-4 p-Bromofentanyl N-(4-bromophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide 117994-23-7 p-Nitrofentanyl [26] N-(4-Nitrophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide Parafluoroisobutyrylbenzylfentanyl N-[(1-benzylpiperidin-4-yl)methyl]-N-(4-fluorophenyl)-2-methylpropanamide 4-Fluorocyclopropylbenzylfentanyl N-(1-benzylpiperidin-4-yl)-N-(4-fluorophenyl)cyclopropanecarboxamide 2344231-47-4 Pivaloylfentanyl 2,2-dimethyl-N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide Pyrrole-fentanyl [27] N-[1-(2-Phenylethyl)piperidin-4-yl]-N-pyrrol-1-ylpropanamide R-30490 N-[4-(Methoxymethyl)-1-(2-phenylethyl)piperidin-4-yl]-N-phenylpropanamide 60618-49-7 瑞芬太尼 methyl 1-(3-methoxy-3-oxopropyl)-4-(N-phenylpropanamido)piperidine-4-carboxylate 132875-61-7 Remifentanil bis ethyl ester ethyl 1-(3-ethoxy-3-oxopropyl)-4-(N-phenylpropanamido)piperidine-4-carboxylate RR49 [28] N1-[2-Fluoro-2-(2-fluorophenyl)ethyl]piperidin-4-ylN-phenylpropanamide 2376328-79-7 SR-16412 [29] 1-(1-benzylpiperidin-4-yl)-3H-indol-2-one 16223-24-8 开环芬太尼[30] N-phenyl-N-{4-[methyl(2-phenylethyl)amino]butan-2-yl}propanamide 253342-66-4 舒芬太尼（英语：sufentanil） N-[4-(Methoxymethyl)-1-(2-thiofuran-2-ylethyl)-4-piperidyl]-N-phenylpropanamide 56030-54-7 Thiafentanil methyl 4-(N-(2-methoxyacetyl)anilino)-1-(2-thiophen-2-ylethyl)piperidine-4-carboxylate 101345-60-2 Thiofentanyl N-phenyl-N-{1-[2-(2-thienyl)ethyl]piperidin-4-yl}propanamide 1165-22-6 Trefentanyl N1-[2-(4-ethyl-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)ethyl]-4-phenylpiperidin-4-ylN-(2-fluorophenyl)propanamide 120656-93-1 Trifluorofentanyl [31] N-(3,4-difluorophenyl)-N-[1-(2-[4-fluorophenyl]ethyl)-4-piperidinyl]-propanamide Tropafentanyl (Fentanyl tropane) N-phenyl-N-[8-(2-phenylethyl)-8-azabicyclo[3.2.1]octan-3-yl]propanamide 3,4-dichloro-4''-methoxyfentanyl N-(3,4-dichlorophenyl)-N-[1-(2-[4-methoxyphenyl]ethyl)-4-piperidinyl]-propanamide 1161705-29-8 参考文献 ^ Schackmuth M, Kerrigan S. Temperature and pH-dependent stability of fentanyl analogs: Degradation pathways and potential biomarkers. J Forensic Sci. 2024 Sep;69(5):1799-1814. doi: 10.1111/1556-4029.15578. Epub 2024 Jul 12. PMID 38997947. ^ Hassanien SH, Bassman JR, Perrien Naccarato CM, Twarozynski JJ, Traynor JR, Iula DM, Anand JP. In vitro pharmacology of fentanyl analogs at the human mu opioid receptor and their spectroscopic analysis. Drug Test Anal. 2020 Aug;12(8):1212-1221. doi: 10.1002/dta.2822. Epub 2020 Jun 11. PMID 32415719; PMCID: PMC8034271. ^ 关于将芬太尼类物质列入《非药用类麻醉药品和精神药品管制品种增补目录》的公告. 中华人民共和国公安部. 2019-03-12 [2025-06-20].  ^ Popławska, M., Bednarek, E., Naumczuk, B. et al. Identification and structure characterization of five synthetic opioids: 3,4-methylenedioxy-U-47700, o-methyl-acetylfentanyl, 2-thiophenefentanyl, benzoylfentanyl and benzoylbenzylfentanyl. Forensic Toxicol 39, 45–58 (2021) doi:10.1007/s11419-020-00539-6 ^ Elbardisy HM, Foster CW, Cumba L, Antonides LH, Gilbert N, Schofield CJ, et al. Analytical determination of heroin, fentanyl and fentalogues using high-performance liquid chromatography with diode array and amperometric detection.. Analytical Methods. 2019, 11 (8): 1053–63. doi:10.1039/C9AY00009G .  ^ Åstrand A, Vikingsson S, Jakobsen I, Björn N, Kronstrand R, Gréen H. Activation of the μ-opioid receptor by alicyclic fentanyls: Changes from high potency full agonists to low potency partial agonists with increasing alicyclic substructure. Drug Testing and Analysis. August 2020, 13 (1): 169–174. PMC 7891621 . PMID 32749741. doi:10.1002/dta.2906 .  ^ Bergh MS, Bogen IL, Nerem E, Wohlfarth A, Wilson SR, Øiestad ÅM. Discovering the major metabolites of the three novel fentanyl analogues 3-methylcrotonylfentanyl, furanylbenzylfentanyl, and 4-fluorocyclopropylbenzylfentanyl for forensic case work.. Forensic Toxicology. 2021, 39: 167–178. S2CID 230110612. doi:10.1007/s11419-020-00560-9.  ^ Rautio T, Vangerven D, Dahlén J, Watanabe S, Kronstrand R, Vikingsson S, et al. In vitro metabolite identification of acetylbenzylfentanyl, benzoylbenzylfentanyl, 3-fluoro-methoxyacetylfentanyl, and 3-phenylpropanoylfentanyl using LC-QTOF-HRMS together with synthesized references. Drug Testing and Analysis. February 2023, 15 (7): 711–729. PMID 36756728. doi:10.1002/dta.3454 .  ^ Varshneya NB, Walentiny DM, Moisa LT, Walker TD, Akinfiresoye LR, Beardsley PM. Opioid-like antinociceptive and locomotor effects of emerging fentanyl-related substances. Neuropharmacology. June 2019, 151: 171–179. PMC 8992608 . PMID 30904478. S2CID 84182661. doi:10.1016/j.neuropharm.2019.03.023.  ^ Faouzi A, Uprety R, Gomes I, Massaly N, Keresztes AI, Le Rouzic V, Gupta A, Zhang T, Yoon HJ, Ansonoff M, Allaoa A, Pan YX, Pintar J, Morón JA, Streicher JM, Devi LA, Majumdar S. Synthesis and Pharmacology of a Novel μ-δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template. Journal of Medicinal Chemistry. November 2020, 63 (22): 13618–13637. PMC 7745089 . PMID 33170687. doi:10.1021/acs.jmedchem.0c00901.  ^ Cooper D, Jacob M, Allen A. Identification of fentanyl derivatives. Journal of Forensic Sciences. April 1986, 31 (2): 511–28. PMID 3711827. doi:10.1520/JFS12283J.  ^ US granted 3161637,Janssen PA,「1-(gamma-aroyl-propyl)-4-(nu-arylcarbonyl amino) piperidines and related compounds」,发行于15 December 1964,指定于Janssen Research Labs  ^ Barceloux DG. Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants.. Wiley. 2012. ISBN 978-0471727606.  ^ Robertson TB, Antonides LH, Gilbert N, Benjamin SL, Langley SK, Munro LJ, Sutcliffe OB, Mewis RE. Hyperpolarization of Pyridyl Fentalogues by Signal Amplification By Reversible Exchange (SABRE). ChemistryOpen. December 2019, 8 (12): 1375–1382. PMC 6892445 . PMID 31844604. doi:10.1002/open.201900273.  ^ W De Silva I, Couch AN, Verbeck GF. Paper Spray Mass Spectrometry Utilized with a Synthetic Microporous Polyolefin Silica Matrix Substrate in the Rapid Detection and Identification of More than 190 Synthetic Fentanyl Analogs. Journal of the American Society for Mass Spectrometry. December 2020, 32 (2): 420–428. PMID 33296202. S2CID 228088741. doi:10.1021/jasms.0c00250.  ^ Lalinde N, Moliterni J, Wright D, Spencer HK, Ossipov MH, Spaulding TC, Rudo FG. Synthesis and pharmacological evaluation of a series of new 3-methyl-1,4-disubstituted-piperidine analgesics. Journal of Medicinal Chemistry. October 1990, 33 (10): 2876–82. PMID 2170652. doi:10.1021/jm00172a032.  ^ Le AD, Alzghari SK. Systematic review of the clinical consequences of butyrfentanyl and corresponding analogues. Interdisciplinary Toxicology. October 2019, 12 (2): 83–88. PMC 7071838 . PMID 32206028. doi:10.2478/intox-2019-0009.  ^ Vincenti F, Montesano C, Di Ottavio F, Gregori A, Compagnone D, Sergi M, Dorrestein P. Molecular Networking: A Useful Tool for the Identification of New Psychoactive Substances in Seizures by LC-HRMS. Frontiers in Chemistry. 2020, 8: 572952. PMC 7723841 . PMID 33324608. doi:10.3389/fchem.2020.572952 .  ^ Oldenhof S, Ten Pierick A, Bruinsma J, Eustace S, Hulshof J, van den Berg J, Hoitink M. Identification of a novel fentanyl analog: p-Hydroxy-butyrylfentanyl. Drug Testing and Analysis. January 2020, 12 (1): 152–155. PMID 31518047. S2CID 202569865. doi:10.1002/dta.2695.  ^ Moore JM, Allen AC, Cooper DA, Carr SM. Determination of fentanyl and related compounds by capillary gas chromatography with electron capture detection. Analytical Chemistry. July 1986, 58 (8): 1656–60. PMID 3752503. doi:10.1021/ac00121a013.  ^ ((Berger, J G.)), ((Davidson, F.)), ((Langford, G E.)). Synthesis of some conformationally restricted analogs of fentanyl. Journal of Medicinal Chemistry. April 1977, 20 (4): 600–602 [November 18, 2022]. ISSN 0022-2623. PMID 850249. doi:10.1021/jm00214a035.  温哥华格式错误 (帮助) 含有連結內容需訂閱查看的頁面 (link) ^ Lobbezoo MW, Soudijn W, van Wijngaarden I. Opiate receptor interaction of compounds derived from or structurally related to fentanyl. Journal of Medicinal Chemistry. July 1981, 24 (7): 777–782. PMID 6268786. doi:10.1021/jm00139a003.  ^ Kennedy NM, Schmid CL, Ross NC, Lovell KM, Yue Z, Chen YT, et al. Optimization of a Series of Mu Opioid Receptor (MOR) Agonists with High G Protein Signaling Bias. Journal of Medicinal Chemistry. October 2018, 61 (19): 8895–8907. PMC 6386185 . PMID 30199635. doi:10.1021/acs.jmedchem.8b01136.  ^ Goicoechea C, Sánchez E, Cano C, Jagerovic N, Martín MI. Analgesic activity and pharmacological characterization of N-[1-phenylpyrazol-3-yl]-N-[1-(2-phenethyl)-4-piperidyl] propenamide, a new opioid agonist acting peripherally. European Journal of Pharmacology. October 2008, 595 (1–3): 22–9. PMID 18706410. doi:10.1016/j.ejphar.2008.07.052.  ^ Kudzma LV, Severnak SA, Benvenga MJ, Ezell EF, Ossipov MH, Knight VV, et al. 4-Phenyl- and 4-heteroaryl-4-anilidopiperidines. A novel class of analgesic and anesthetic agents. Journal of Medicinal Chemistry. December 1989, 32 (12): 2534–2542. PMID 2585442. doi:10.1021/jm00132a007.  ^ Stojanović A, Jevtic I, Krunić M, Ivanovic M. Synthesis of para-nitro fentanyl. 8th Conference of Young Chemists of Serbia. October 2022.  ^ US 4452803,Effland RC, Klein JT,「Pyrrolylaminopiperidines.」,发行于19 September 1983  ^ Rosas R, Huang XP, Roth BL, Dockendorff C. β-Fluorofentanyls Are pH-Sensitive Mu Opioid Receptor Agonists. ACS Medicinal Chemistry Letters. September 2019, 10 (9): 1353–1356. PMC 6746189 . PMID 31531209. doi:10.1021/acsmedchemlett.9b00335.  ^ Zaveri NT, Jiang F, Olsen CM, Deschamps JR, Parrish D, Polgar W, Toll L. A novel series of piperidin-4-yl-1,3-dihydroindol-2-ones as agonist and antagonist ligands at the nociceptin receptor. Journal of Medicinal Chemistry. June 2004, 47 (12): 2973–6. PMC 3852901 . PMID 15163178. doi:10.1021/jm034249d.  ^ Ivanović MD, Mićović I, Vučković S, Prostran M, Todorović Z, Ivanović E, Kiricojević V, Đorđević JB, Došen-Mićović L. The synthesis and pharmacological evaluation of (+/-)-2, 3-seco-fentanyl analogues.. Journal of the Serbian Chemical Society. 2004, 69 (11): 955–68. doi:10.2298/JSC0411955I .  ^ US abandoned 2011046180,Peters D, Eriksen BL, Munro G, Nielsen EØ,「N-aryl-n-piperidin-4-yl-propionamide derivatives and their use as opioid receptor ligands」,指定于Neurosearch AS  外部链接 Fentanyl landscape | PiHKAL · info. isomerdesign.com.

Index: pl ar de en es fr it arz nl ja pt ceb sv uk vi war zh ru af ast az bg zh-min-nan bn be ca cs cy da et el eo eu fa gl ko hi hr id he ka la lv lt hu mk ms min no nn ce uz kk ro simple sk sl sr sh fi ta tt th tg azb tr ur zh-yue hy my ace als am an hyw ban bjn map-bms ba be-tarask bcl bpy bar bs br cv nv eml hif fo fy ga gd gu hak ha hsb io ig ilo ia ie os is jv kn ht ku ckb ky mrj lb lij li lmo mai mg ml zh-classical mr xmf mzn cdo mn nap new ne frr oc mhr or as pa pnb ps pms nds crh qu sa sah sco sq scn si sd szl su sw tl shn te bug vec vo wa wuu yi yo diq bat-smg zu lad kbd ang smn ab roa-rup frp arc gn av ay bh bi bo bxr cbk-zam co za dag ary se pdc dv dsb myv ext fur gv gag inh ki glk gan guw xal haw rw kbp pam csb kw km kv koi kg gom ks gcr lo lbe ltg lez nia ln jbo lg mt mi tw mwl mdf mnw nqo fj nah na nds-nl nrm nov om pi pag pap pfl pcd krc kaa ksh rm rue sm sat sc trv stq nso sn cu so srn kab roa-tara tet tpi to chr tum tk tyv udm ug vep fiu-vro vls wo xh zea ty ak bm ch ny ee ff got iu ik kl mad cr pih ami pwn pnt dz rmy rn sg st tn ss ti din chy ts kcg ve

Prefix: a b c d e f g h i j k l m n o p q r s t u v w x y z 0 1 2 3 4 5 6 7 8 9

Portal di Ensiklopedia Dunia

Agama

Bahasa

Biografi

Budaya

Ekonomi

Elektronika

Film

Filsafat

Geografi

Indonesia

Ilmu

Lingkungan

Masyarakat

Matematika

Militer

Mitologi

Musik

Olahraga

Pendidikan

Politik

Sastra

Sejarah

Seni

Teknologi