黄体生成素/绒毛膜促性腺激素受体

黄体生成素/绒毛膜促性腺激素受体
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	7FIG、7FIH、7FII、7FIJ
識別號
别名	LHCGR；, HHG, LCGR, LGR2, LH/CG-R, LH/CGR, LHR, LHRHR, LSH-R, ULG5, Luteinizing hormone/choriogonadotropin receptor
外部ID	OMIM：152790 MGI：96783 HomoloGene：37276 GeneCards：LHCGR
相關疾病
	leydig cell hypoplasia, type 1
為以下藥物的標靶
	lutropin alfa
基因位置（人类）
染色体	2號染色體
终止	48,755,730 bp
基因位置（小鼠）
染色体	小鼠17号染色体
终止	89,099,418 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• G protein-coupled peptide receptor activity; • G protein-coupled receptor activity; • choriogonadotropin hormone binding; • signal transducer activity; • protein-hormone receptor activity; • choriogonadotropin hormone receptor activity; • follicle-stimulating hormone receptor activity; • luteinizing hormone receptor activity;
細胞組分	• integral component of membrane; • 核内体; • 膜; • integral component of plasma membrane; • 细胞膜;
生物學過程	• G protein-coupled receptor signaling pathway; • male gonad development; • male genitalia development; • 認知; • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; • activation of adenylate cyclase activity; • positive regulation of inositol trisphosphate biosynthetic process; • hormone-mediated signaling pathway; • cellular response to gonadotropin stimulus; • 訊息傳遞; • primary ovarian follicle growth; • phospholipase C-activating G protein-coupled receptor signaling pathway; • follicle-stimulating hormone signaling pathway; • regulation of osteoclast differentiation; • luteinizing hormone signaling pathway; • positive regulation of adenylate cyclase activity; • cellular response to luteinizing hormone stimulus; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • ovulation cycle process;
	Sources:Amigo / QuickGO
直系同源
	3973
	16867
	ENSG00000138039
	ENSMUSG00000024107
	P22888
	P30730
	NM_000233
	NM_013582; NM_001364898
	NP_000224
	NP_038610; NP_001351827
	維基數據
檢視/編輯人類	檢視/編輯小鼠

黄体生成素/绒毛膜促性腺激素受体（英語：luteinizing hormone/choriogonadotropin receptor，缩写LHCGR也作 lutropin/choriogonadotropin receptor，LCGR或luteinizing hormone receptor，LHR ）是一种主要出现在卵巢和睾丸的跨膜受体，但在一些性腺外的器官如子宫和乳房也有表达。该受体是G蛋白偶联受体（GPCR）的一种，既能与黄体生成素（LH）也能与绒毛膜促性腺激素（如人类的hCG）相互作用，其激活是在繁殖期间的荷尔蒙运作所需的。

LHCGR基因

LHCGR位于人类基因组上的2號染色體p21区，接近类似的促卵泡激素受体（FSHR）基因，长约70Kbp（FSHR为54Kpb）^[7]，除了与FSHR相似外，还类似于促甲状腺激素受体（TSHR）。

历史

馬丁·羅德貝爾与艾爾佛列·古曼·吉爾曼因发现G蛋白系统而获得1994年的诺贝尔生理学或医学奖。

相互作用

黄体生成素/绒毛膜促性腺激素受体与GIPC1能进行相互作用^[8]。

参考文献

^ 與黄体生成素/绒毛膜促性腺激素受体相關的疾病；在維基數據上查看/編輯參考.
^ 對luteinizing hormone/choriogonadotropin receptor起作用的藥物；在維基數據上查看/編輯參考.
^ ^3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000138039 - Ensembl, May 2017
^ ^4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000024107 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Simoni M, Gromoll J, Nieschlag E. The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology. Endocr. Rev. 1997, 18 (6): 739–73. PMID 9408742. doi:10.1210/er.18.6.739.
^ Hirakawa, Takashi; Galet Colette; Kishi Mikiko; Ascoli Mario. GIPC binds to the human lutropin receptor (hLHR) through an unusual PDZ domain binding motif, and it regulates the sorting of the internalized human choriogonadotropin and the density of cell surface hLHR. J. Biol. Chem. (United States). Dec 2003, 278 (49): 49348–57. ISSN 0021-9258. PMID 14507927. doi:10.1074/jbc.M306557200.

延伸阅读

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