PDZ结构域

現有可用的蛋白結構：
Pfam	結構（旧版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum（英语：PDBsum）	結構概要
PDB	1l1jB:248-262 1lcyA:388-442 1fc7A:151-232 1fc9A:151-232 1fcfA:151-232 1fc6A:151-232 1ueqA:426-492 1ujvA:639-680 1i92A:14-91 1g9oA:14-91 1q3oA:663-754 1q3pA:663-754 1uepA:778-859 1wfvA:1147-1226 1uewA:920-1007 2cs5A:517-602 1qavA:81-161 2pdzA:81-161 1z86A:81-161 1z87A:81-161 1pdr :466-544 1tq3A:313-391 1be9A:313-391 1bfeA:313-391 1tp5A:313-391 1tp3A:313-391 1um7A:386-464 1iu2A:65-149 1iu0A:65-149 1kefA:65-149 1zokA:224-308 1qlcA:160-244 2bygA:193-277 2fe5A:226-310 1wi2A:47-125 1whaA:871-947 1x5qA: 728-812 1t2mA:993-1073 1um1A:974-1056 1wf8A:504-589 1gm1A:1357-1439 1oziA:1357-1439 1vj6A:1357-1439 1d5gA:1368-1450 3pdzA:1368-1450 1q7xA:1368-1450 1ujuA:1100-1189 1wi4A:22-94 1l6oA:254-339 1mc7A:251-336 1n7tA:1323-1407 1mfgA:1323-1407 1mflA:1323-1407 1uezA:140-219 1uf1A:279-357 1x5nA:211-289 1ihjA:17-103 1uhpA:249-336 1uitA:1240-1316 1x6dA:412-495 2csjA:10-94 1m5zA:988-1067 2cssA:605-688 1zubA:619-702 1wfgA:668-753 1ufxA:816-887 1qauA:17-96 1b8qA:17-96 1u38A:656-740 1u37A:656-740 1u3bA:656-740 1x45A:656-740 1p1dA:471-557 1p1eA:471-557 1x5rA:456-542 1v62A:248-329 1n7fA:672-751 1n7eA:672-751 1wf7A:5-82 1rgwA:4-81 1vb7A:3-81 1i16 :533-616 1v6bA:752-838 2f5yB:300-373 1whdA:18-92 1yboA:114-191 1v1tB:114-191 1obzB:114-191 1n99A:114-191 1wh1A:419-501 1va8A:256-333 1kwaA:490-568 1nf3D:157-247 1rzxA:160-250 1obyB:198-270 1obxA:198-270 1nteA:198-270 1r6jA:198-270 1u39A:747-820 1y7nA:747-820

鑑定
標誌	PDZ
Pfam	PF00595（旧版）
InterPro（英语：InterPro）	IPR001478
SMART（英语：Simple Modular Architecture Research Tool）	PDZ
PROSITE（英语：PROSITE）	PDOC50106
SCOP（英语：Structural Classification of Proteins）	1lcy / SUPFAM
CDD（英语：Conserved Domain Database）	cd00136
Pfam
現有可用的蛋白結構：
Pfam	結構（旧版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum（英语：PDBsum）	結構概要
PDB	1l1jB:248-262 1lcyA:388-442 1fc7A:151-232 1fc9A:151-232 1fcfA:151-232 1fc6A:151-232 1ueqA:426-492 1ujvA:639-680 1i92A:14-91 1g9oA:14-91 1q3oA:663-754 1q3pA:663-754 1uepA:778-859 1wfvA:1147-1226 1uewA:920-1007 2cs5A:517-602 1qavA:81-161 2pdzA:81-161 1z86A:81-161 1z87A:81-161 1pdr :466-544 1tq3A:313-391 1be9A:313-391 1bfeA:313-391 1tp5A:313-391 1tp3A:313-391 1um7A:386-464 1iu2A:65-149 1iu0A:65-149 1kefA:65-149 1zokA:224-308 1qlcA:160-244 2bygA:193-277 2fe5A:226-310 1wi2A:47-125 1whaA:871-947 1x5qA: 728-812 1t2mA:993-1073 1um1A:974-1056 1wf8A:504-589 1gm1A:1357-1439 1oziA:1357-1439 1vj6A:1357-1439 1d5gA:1368-1450 3pdzA:1368-1450 1q7xA:1368-1450 1ujuA:1100-1189 1wi4A:22-94 1l6oA:254-339 1mc7A:251-336 1n7tA:1323-1407 1mfgA:1323-1407 1mflA:1323-1407 1uezA:140-219 1uf1A:279-357 1x5nA:211-289 1ihjA:17-103 1uhpA:249-336 1uitA:1240-1316 1x6dA:412-495 2csjA:10-94 1m5zA:988-1067 2cssA:605-688 1zubA:619-702 1wfgA:668-753 1ufxA:816-887 1qauA:17-96 1b8qA:17-96 1u38A:656-740 1u37A:656-740 1u3bA:656-740 1x45A:656-740 1p1dA:471-557 1p1eA:471-557 1x5rA:456-542 1v62A:248-329 1n7fA:672-751 1n7eA:672-751 1wf7A:5-82 1rgwA:4-81 1vb7A:3-81 1i16 :533-616 1v6bA:752-838 2f5yB:300-373 1whdA:18-92 1yboA:114-191 1v1tB:114-191 1obzB:114-191 1n99A:114-191 1wh1A:419-501 1va8A:256-333 1kwaA:490-568 1nf3D:157-247 1rzxA:160-250 1obyB:198-270 1obxA:198-270 1nteA:198-270 1r6jA:198-270 1u39A:747-820 1y7nA:747-820

PDZ结构域（英語：PDZ domain）是一个长约80-90个氨基酸残基的蛋白质结构域，广泛存在于细菌、真菌、植物、病毒^[1]、以及动物^[2]的信号转导相关蛋白中。

参考文献

^ Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L. The HTLV-1 Tax interactome. Retrovirology. August 2008, 5: 76. PMC 2533353 . PMID 18702816. doi:10.1186/1742-4690-5-76 .
^ Ponting CP. Evidence for PDZ domains in bacteria, yeast, and plants. Protein Science. February 1997, 6 (2): 464–8. PMC 2143646 . PMID 9041651. doi:10.1002/pro.5560060225.

外部链接

Eukaryotic Linear Motif resource motif class LIG_PDZ_Class_1
Eukaryotic Linear Motif resource motif class LIG_PDZ_Class_2
Eukaryotic Linear Motif resource motif class LIG_PDZ_Class_3
The PDZ Domain as a Complex Adaptive System A concise technical summary and a statement of principal findings and ramifications of the PDZ Domain as a Complex Adaptive System
NCBI conserved domains entry
https://www.pdznet.eu - An EU project to advance our understanding of the cellular signaling pathways and therapeutic potential of proteins comprising PDZ domains in healthy and pathological conditions such as cancer and neurological diseases.

[pmid18702816-1] Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L. The HTLV-1 Tax interactome. Retrovirology. August 2008, 5: 76. PMC 2533353 . PMID 18702816. doi:10.1186/1742-4690-5-76 .

[pmid9041651-2] Ponting CP. Evidence for PDZ domains in bacteria, yeast, and plants. Protein Science. February 1997, 6 (2): 464–8. PMC 2143646 . PMID 9041651. doi:10.1002/pro.5560060225.

[1]

[2]

PDZ结构域

参考文献

外部链接

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