Dronedaron

Dronedaron
Klinički podaci
Drugs.com	Monografija
Način primene	Oralno
Farmakokinetički podaci
Poluvreme eliminacije	13-19 h
Izlučivanje	Renalno
Identifikatori
CAS broj	141626-36-0
ATC kod	C01BD07 (WHO)
PubChem	CID 208898
DrugBank	DB04855
ChemSpider	180996
ChEBI	CHEBI:50659
ChEMBL	CHEMBL184412
Hemijski podaci
Formula	C31H44N2O5S
Molarna masa	556,756
	SMILES CCCCN(CCCC)CCCOC1=CC=C(C=C1)C(=O)C1=C(CCCC)OC2=C1C=C(NS(C)(=O)=O)C=C2; ;
	InChI InChI=1S/C31H44N2O5S/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3/h13-18,23,32H,5-12,19-22H2,1-4H3 ; Key:ZQTNQVWKHCQYLQ-UHFFFAOYSA-N ;

Dronedaron je organsko jedinjenje, koje sadrži 31 atom ugljenika i ima molekulsku masu od 556,756 Da.^[1]^[2]^[3]^[4]^[5]^[6]^[7]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	5
Broj donora vodonika	1
Broj rotacionih veza	18
Particioni koeficijent^[8] (ALogP)	7,0
Rastvorljivost^[9] (logS, log(mol/L))	-9,7
Polarna površina^[10] (PSA, Å²)	97,2

Reference

^ Dale KM, White CM: Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter. Ann Pharmacother. Dale, K. M.; White, C. M. (2007 Apr). „Dronedarone: An amiodarone analog for the treatment of atrial fibrillation and atrial flutter”. The Annals of Pharmacotherapy. 41 (4): 599—605. PMID 17389667. doi:10.1345/aph.1H524. Проверите вредност парамет(а)ра за датум: |date= (помоћ). Epub 2007 Mar 27.
^ Iwamoto T, Watanabe Y, Kita S, Blaustein MP. Iwamoto, T.; Watanabe, Y.; Kita, S.; Blaustein, M. P. (2007 Sep). „Na+/Ca2+ exchange inhibitors: a new class of calcium regulators”. Cardiovasc Hematol Disord Drug Targets. 7 (3): 188—98. PMID 17896959. doi:10.2174/187152907781745288. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Celestino D, Medei E, Moro S, Elizari MV, Sicouri S. Celestino, D.; Medei, E.; Moro, S.; Elizari, M. V.; Sicouri, S. (2007 Sep). „Acute in vitro effects of dronedarone, an iodine-free derivative, and amiodarone, on the rabbit sinoatrial node automaticity: a comparative study”. J Cardiovasc Pharmacol Ther. 12 (3): 248—57. PMID 17875953. doi:10.1177/1074248407303225. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Pamukcu B, Lip GY: Dronedarone as a new treatment option for atrial fibrillation patients: pharmacokinetics, pharmacodynamics and clinical practice. Expert Opin Pharmacother. Pamukcu, Burak; Lip, Gregory YH (2011 Jan). „Dronedarone as a new treatment option for atrial fibrillation patients: Pharmacokinetics, pharmacodynamics and clinical practice”. Expert Opinion on Pharmacotherapy. 12 (1): 131—40. PMID 21126199. doi:10.1517/14656566.2011.540800. Проверите вредност парамет(а)ра за датум: |date= (помоћ).. Epub 2010 Dec 2.
^ De Ferrari GM, Dusi V: Drug safety evaluation of dronedarone in atrial fibrillation. Expert Opin Drug Saf. De Ferrari, Gaetano M.; Dusi, Veronica (2012 Nov). „Drug safety evaluation of dronedarone in atrial fibrillation”. Expert Opinion on Drug Safety. 11 (6): 1023—45. PMID 22971242. doi:10.1517/14740338.2012.722994. Проверите вредност парамет(а)ра за датум: |date= (помоћ).. Epub 2012 Sep 13.
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.