Prilokain

Prilokain
Klinički podaci
Prodajno ime	Astra 1512, Astra 1515, Citanest, Citanest Plain
Drugs.com	Monografija
Način primene	Infiltration
Farmakokinetički podaci
Izlučivanje	Renalno
Identifikatori
CAS broj	721-50-6
ATC kod	N01BB04 (WHO)
PubChem	CID 4906
DrugBank	DB00750
ChemSpider	4737
KEGG	C07531
ChEBI	CHEBI:8404
ChEMBL	CHEMBL1194
Hemijski podaci
Formula	C13H20N2O
Molarna masa	220,311
	SMILES CCCNC(C)C(=O)NC1=CC=CC=C1C; ;
	InChI InChI=1S/C13H20N2O/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2/h5-8,11,14H,4,9H2,1-3H3,(H,15,16) ; Key:MVFGUOIZUNYYSO-UHFFFAOYSA-N ;
Fizički podaci
Tačka topljenja	37—38 °C (99—100 °F)
Tačka ključanja	159 °C (318 °F)

Prilokain je organsko jedinjenje, koje sadrži 13 atoma ugljenika i ima molekulsku masu od 220,311 Da.^[1]^[2]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	2
Broj donora vodonika	2
Broj rotacionih veza	5
Particioni koeficijent^[3] (ALogP)	2,3
Rastvorljivost^[4] (logS, log(mol/L))	-3,5
Polarna površina^[5] (PSA, Å²)	41,1

Reference

^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.