Алфред Г. Гилман

Алфред Г. Гилман
Алфред Г. Гилман
	Гилман 1994.
Лични подаци
Датум рођења	1. јул 1941.
Место рођења	Њу Хејвен, САД
Датум смрти	23. децембар 2015. (74 год.)
Место смрти	Далас, САД
Образовање	Универзитет Јејл, Универзитет Вирџиније, Case Western Reserve University
Научни рад
Поље	Фармакологија
Институција	Case Western Reserve University
Познат по	Г-протеин
Награде	Нобелова награда за физиологију или медицину (1994)

Алфред Гудман Гилман (енгл. Alfred Goodman Gilman; Њу Хејвен, 1. јул 1941 — Далас, 23. децембар 2015) био је амерички биохемичар и фармаколог, који се прославио открићем Г-протеина и улогом протеина у преносу сигнала у ћелијама. За ово откриће додељена му је Нобелова награда за физиологију или медицину, заједно са Мартином Родбелом 1994.^[1]^[2]^[3]

Галерија

Библиографија

Seeds, N. W.; Gilman, A. G. (1971). „Norepinephrine stinulated increase of cyclic AMP levels in developing mouse brain cell cultures”. Science. 174 (4006): 292. Bibcode:1971Sci...174..292S. PMID 4330303. S2CID 98674465. doi:10.1126/science.174.4006.292. .
Gilman, A. G.; Nirenberg, M. (1971-12-10). „Regulation of adenosine 3',5'-cyclic monophosphate metabolism in cultured neuroblastoma cells”. Nature. 234 (5328): 356—8. Bibcode:1971Natur.234..356G. PMID 4332686. S2CID 4169292. doi:10.1038/234356a0. .
Secrist Ja, 3rd; Barrio, J. R.; Leonard, N. J.; Villar-Palasi, C.; Gilman, A. G. (1972-07-21). „Fluorescent modification of adenosine 3',5'-monophosphate: Spectroscopic properties and activity in enzyme systems”. Science. 177 (45): 279—80. Bibcode:1972Sci...177..279S. PMID 4339302. S2CID 23752942. doi:10.1126/science.177.4045.279. .
Sternweis, P. C.; Northup, J. K.; Smigel, M. D.; Gilman, A. G. (1981-11-25). „The regulatory component of adenylate cyclase. Purification and properties”. The Journal of Biological Chemistry. 256 (22): 11517—26. PMID 6271754. doi:10.1016/S0021-9258(19)68431-0 . .
Hanski, E.; Sternweis, P. C.; Northup, J. K.; Dromerick, A. W.; Gilman, A. G. (1981-12-25). „The regulatory component of adenylate cyclase. Purification and properties of the turkey erythrocyte protein”. The Journal of Biological Chemistry. 256 (24): 12911—9. PMID 6273414. doi:10.1016/S0021-9258(18)42983-3 . .
Schleifer, L. S.; Kahn, R. A.; Hanski, E.; Northup, J. K.; Sternweis, P. C.; Gilman, A. G. (1982-01-10). „Requirements for cholera toxin-dependent ADP-ribosylation of the purified regulatory component of adenylate cyclase”. The Journal of Biological Chemistry. 257 (1): 20—3. PMID 6273425. doi:10.1016/S0021-9258(19)68316-X . .
Northup, J. K.; Smigel, M. D.; Gilman, A. G. (1982-10-10). „The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding”. The Journal of Biological Chemistry. 257 (19): 11416—23. PMID 6288684. doi:10.1016/S0021-9258(18)33775-X . .
Manning, D. R.; Gilman, A. G. (1983-06-10). „The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins”. The Journal of Biological Chemistry. 258 (11): 7059—63. PMID 6304074. doi:10.1016/S0021-9258(18)32332-9 . .
Northup, J. K.; Sternweis, P. C.; Gilman, A. G. (1983-09-25). „The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (Beta) subunit”. The Journal of Biological Chemistry. 258 (18): 11361—8. PMID 6309843. doi:10.1016/S0021-9258(17)44426-7 . .
Northup, J. K.; Smigel, M. D.; Sternweis, P. C.; Gilman, A. G. (1983-09-25). „The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (Alpha) subunit”. The Journal of Biological Chemistry. 258 (18): 11369—76. PMID 6309844. doi:10.1016/S0021-9258(17)44427-9 . .
Hurley, J. B.; Simon, M. I.; Teplow, D. B.; Robishaw, J. D.; Gilman, A. G. (1984-11-16). „Homologies between signal transducing G proteins and ras gene products”. Science. 226 (4676): 860—2. Bibcode:1984Sci...226..860H. PMID 6436980. doi:10.1126/science.6436980. .
Gilman, A. G. (март 1984). „G proteins and dual control of adenylate cyclase”. Cell. 36 (3): 577—9. PMID 6321035. S2CID 36861537. doi:10.1016/0092-8674(84)90336-2. .
Bokoch, G. M.; Gilman, A. G. (1984). „Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin”. Cell. 39 (2 Pt 1): 301—308. PMID 6094010. S2CID 10507727. doi:10.1016/0092-8674(84)90008-4. .
Harris, B. A.; Robishaw, J. D.; Mumby, S. M.; Gilman, A. G. (1985-09-20). „Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase”. Science. 229 (4719): 1274—7. Bibcode:1985Sci...229.1274H. PMID 3839937. doi:10.1126/science.3839937. .
Mattera, R.; Graziano, M. P.; Yatani, A.; Zhou, Z.; Graf, R.; Codina, J.; Birnbaumer, L.; Gilman, A. G.; Brown, A. M. (1989-02-10). „Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels”. Science. 243 (4892): 804—7. Bibcode:1989Sci...243..804M. PMID 2536957. doi:10.1126/science.2536957. .
Krupinski, J.; Coussen, F.; Bakalyar, H. A.; Tang, W. J.; Feinstein, P. G.; Orth, K.; Slaughter, C.; Reed, R. R.; Gilman, A. G. (1989-06-30). „Adenylyl cyclase amino acid sequence: Possible channel- or transporter-like structure”. Science. 244 (4912): 1558—64. Bibcode:1989Sci...244.1558K. PMID 2472670. doi:10.1126/science.2472670. .
Tang, W. J.; Gilman, A. G. (1991-12-06). „Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits”. Science. 254 (5037): 1500—3. Bibcode:1991Sci...254.1500T. PMID 1962211. doi:10.1126/science.1962211. .
Taussig, R.; Iñiguez-Lluhi, J. A.; Gilman, A. G. (1993-07-09). „Inhibition of adenylyl cyclase by Gi alpha”. Science. 261 (5118): 218—21. Bibcode:1993Sci...261..218T. PMID 8327893. doi:10.1126/science.8327893. .
Wickman, K. D.; Iñiguez-Lluhl, J. A.; Davenport, P. A.; Taussig, R.; Krapivinsky, G. B.; Linder, M. E.; Gilman, A. G.; Clapham, D. E. (1994-03-17). „Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel”. Nature. 368 (6468): 255—7. Bibcode:1994Natur.368..255W. PMID 8145826. S2CID 4367498. doi:10.1038/368255a0. .
Coleman, D. E.; Berghuis, A. M.; Lee, E.; Linder, M. E.; Gilman, A. G.; Sprang, S. R. (1994). „Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis”. Science. 265 (5177): 1405—1412. Bibcode:1994Sci...265.1405C. PMID 8073283. doi:10.1126/science.8073283. .
Tang, W. J.; Gilman, A. G. (1995-06-23). „Construction of a soluble adenylyl cyclase activated by Gs alpha and forskolin”. Science. 268 (5218): 1769—72. Bibcode:1995Sci...268.1769T. PMID 7792604. doi:10.1126/science.7792604. .
Mixon, M. B.; Lee, E.; Coleman, D. E.; Berghuis, A. M.; Gilman, A. G.; Sprang, S. R. (1995-11-10). „Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis”. Science. 270 (5238): 954—60. Bibcode:1995Sci...270..954M. PMID 7481799. S2CID 86608235. doi:10.1126/science.270.5238.954. .
Wall, M. A.; Coleman, D. E.; Lee, E.; Iñiguez-Lluhi, J. A.; Posner, B. A.; Gilman, A. G.; Sprang, S. R. (1995-12-15). „The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2”. Cell. 83 (6): 1047—58. PMID 8521505. S2CID 18993038. doi:10.1016/0092-8674(95)90220-1. .
Berman, D. M.; Wilkie, T. M.; Gilman, A. G. (1996). „GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits”. Cell. 86 (3): 445—452. PMID 8756726. S2CID 12427406. doi:10.1016/s0092-8674(00)80117-8. .
Sunahara, R. K.; Tesmer, J. J.; Gilman, A. G.; Sprang, S. R. (1997-12-12). „Crystal structure of the adenylyl cyclase activator Gsalpha”. Science. 278 (5345): 1943—7. Bibcode:1997Sci...278.1943S. PMID 9395396. doi:10.1126/science.278.5345.1943. .
Tesmer, J. J.; Sunahara, R. K.; Gilman, A. G.; Sprang, S. R. (1997-12-12). „Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.”. Science. 278 (5345): 1907—16. Bibcode:1997Sci...278.1907T. PMID 9417641. doi:10.1126/science.278.5345.1907. .

Референце

^ Seeds, Nicholas W.; Gilman, Alfred G. (1971). „Norepinephrine Stimulated Increase of Cyclic AMP Levels in Developing Mouse Brain Cell Cultures”. Science. 174 (4006): 292. Bibcode:1971Sci...174..292S. PMID 4330303. S2CID 98674465. doi:10.1126/science.174.4006.292.
^ Gilman, Alfred G.; Nirenberg, Marshall (1971). „Regulation of Adenosine 3′,5′-Cyclic Monophosphate Metabolism in Cultured Neuroblastoma Cells”. Nature. 234 (5328): 356—358. Bibcode:1971Natur.234..356G. PMID 4332686. S2CID 4169292. doi:10.1038/234356a0.
^ Secrist, John A.; Barrio, Jorge R.; Leonard, Nelson J.; Villar-Palasi, Carlos; Gilman, Alfred G. (1972). „Fluorescent Modification of Adenosine 3′,5′-Monophosphate: Spectroscopic Properties and Activity in Enzyme Systems”. Science. 177 (4045): 279—280. Bibcode:1972Sci...177..279S. PMID 4339302. S2CID 23752942. doi:10.1126/science.177.4045.279.

Литература

Rasmussen, Søren G. F.; Devree, Brian T.; Zou, Yaozhong; Kruse, Andrew C.; Chung, Ka Young; Kobilka, Tong Sun; Thian, Foon Sun; Chae, Pil Seok; Pardon, Els; Calinski, Diane; Mathiesen, Jesper M.; Shah, Syed T. A.; Lyons, Joseph A.; Caffrey, Martin; Gellman, Samuel H.; Steyaert, Jan; Skiniotis, Georgios; Weis, William I.; Sunahara, Roger K.; Kobilka, Brian K. (2011). „Crystal structure of the β2 adrenergic receptor–Gs protein complex”. Nature. 477 (7366): 549—555. Bibcode:2011Natur.477..549R. PMC 3184188 . PMID 21772288. doi:10.1038/nature10361.
(језик: енглески) Authors' summary on the structure (Science) (Приступљено 26 Nov. 2007)