右艾夫他滨

右艾夫他滨
	IUPAC名; 2′,3′-Didehydro-2′,3′-dideoxy-5-fluorocytidine
	系统名; 4-Amino-5-fluoro-1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-1-yl]pyrimidin-2(1H)-one
别名	Reverset
识别
CAS号	134379-77-4
PubChem	64973
ChemSpider	58498
SMILES	F\C1=C\N(C(=O)\N=C1\N)[C@@H]/2O[C@@H](\C=C\2)CO;
InChI	1/C9H10FN3O3/c10-6-3-13(9(15)12-8(6)11)7-2-1-5(4-14)16-7/h1-3,5,7,14H,4H2,(H2,11,12,15)/t5-,7+/m0/s1;
InChIKey	HSBKFSPNDWWPSL-CAHLUQPWBD
KEGG	D03981
性质
化学式	C9H10FN3O3
摩尔质量	227.19 g·mol−1
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

右艾夫他滨（INN：Dexelvucitabine）是一种用于治疗人类免疫缺陷病毒感染的实验药物，不过已经研发失败。它是一种胞苷核苷类似物和核苷逆转录酶抑制剂。^[1]，可在体外抑制HIV-1复制。在II期临床试验中，有一些迹象表明，感染人类免疫缺陷病毒的患者的平均病毒载量有所下降。^[2]^[3]

2006年4月3日，开发右艾夫他滨的制药公司Pharmasset（英语：Pharmasset）和因赛特宣布决定停止该药物的进一步试验和开发，因为在II期临床试验中4级高脂酶血症（血液中脂肪酶过量）的发生率增加。^[1]^[4]

参考资料

^ ^1.0 ^1.1 PubChem. Dexelvucitabine. pubchem.ncbi.nlm.nih.gov. [2022-04-07] （英语）.
^ Hernandez-Santiago, Brenda I.; Mathew, Judy S.; Rapp, Kim L.; Grier, Jason P.; Schinazi, Raymond F. Antiviral and Cellular Metabolism Interactions between Dexelvucitabine and Lamivudine. Antimicrobial Agents and Chemotherapy. June 2007, 51 (6): 2130–2135. ISSN 0066-4804. PMC 1891415 . PMID 17403996. doi:10.1128/aac.01543-06.
^ Sobieszczyk, Magdalena E; Talley, Angela K; Wilkin, Timothy; Hammer, Scott M. Advances in antiretroviral therapy. Topics in HIV Medicine. 2005-03-01, 13 (1): 24–44 [2024-03-04]. ISSN 2161-5845. PMID 15849370. （原始内容存档于2024-03-04）.
^ Ryder, Neil S. Discontinued drugs in 2006: anti-infectives. Expert Opinion on Investigational Drugs. 2007-12-01, 16 (12): 1867–1878. ISSN 1354-3784. PMID 18041997. S2CID 40129603. doi:10.1517/13543784.16.12.1867.

[:0-1] 1.0 ^1.1 PubChem. Dexelvucitabine. pubchem.ncbi.nlm.nih.gov. [2022-04-07] （英语）.

[2] Hernandez-Santiago, Brenda I.; Mathew, Judy S.; Rapp, Kim L.; Grier, Jason P.; Schinazi, Raymond F. Antiviral and Cellular Metabolism Interactions between Dexelvucitabine and Lamivudine. Antimicrobial Agents and Chemotherapy. June 2007, 51 (6): 2130–2135. ISSN 0066-4804. PMC 1891415 . PMID 17403996. doi:10.1128/aac.01543-06.

[3] Sobieszczyk, Magdalena E; Talley, Angela K; Wilkin, Timothy; Hammer, Scott M. Advances in antiretroviral therapy. Topics in HIV Medicine. 2005-03-01, 13 (1): 24–44 [2024-03-04]. ISSN 2161-5845. PMID 15849370. （原始内容存档于2024-03-04）.

[4] Ryder, Neil S. Discontinued drugs in 2006: anti-infectives. Expert Opinion on Investigational Drugs. 2007-12-01, 16 (12): 1867–1878. ISSN 1354-3784. PMID 18041997. S2CID 40129603. doi:10.1517/13543784.16.12.1867.

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右艾夫他滨

参考资料

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