Секретин

Секретин
Секретин
Идентификатори
Симбол	SCT
Entrez	6343
HUGO	10607
OMIM	182099
RefSeq	NM_021920
UniProt	P09683
Остали подаци
Локус	Хромозом 11 p15.5

Секретин
Секретин
Идентификатори
Симбол	SCT
Вањски ИД	OMIM: 182099 MGI: 99466 HomoloGene: 7928 GeneCards: SCT Gene
Онтологија гена
Молекулска функција	• хормонска активност;
Ћелијска компонента	• екстрацелуларни регион;
Биолошки процес	• сигнални пут Г-протеин спрегнутог рецептора; • секреција панкреасног сока;
Ортолози
Врста	Човек
Ентрез	6343
Eнсембл	ENSG00000070031
UниПрот	P09683
Реф. Секв. (иРНК)	NM_021920
Реф. Секв. (протеин)	NP_068739
Локација (УЦСЦ)	Chr 11:; 0.62 - 0.62 Mb
ПубМед претрага	[1]

Секретин је хормон дигестивног система који луче С ћелије дванаестопалачног црева, стимулише секрецију течности богатих бикарбонатима из панкреаса и јетре.^[1]^[2]

Референце

^ Häcki, W. H. (1980). „Secretin”. Clin Gastroenterol. 9 (3): 609—32. PMID 7000396.
^ Whitmore TE, Holloway JL, Lofton-Day CE, Maurer MF, Chen L, Quinton TJ, Vincent JB, Scherer SW, Lok S (2000). „Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA”. Cytogenet. Cell Genet. 90 (1-2): 47—52. PMID 11060443. doi:10.1159/000015658.

Додатна литература

E, Saus; A, Brunet; L, Armengol (2010). „Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.”. Journal of psychiatric research. 44 (14): HASH(0x117c470). PMID 20398908. doi:10.1016/j.jpsychires.2010.03.007.
GP, Bertenshaw; BE, Turk; SJ, Hubbard (2001). „Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity.”. J. Biol. Chem. 276 (16): 13248—55. PMID 11278902. doi:10.1074/jbc.M011414200.
Lee LT, Lam IP, Chow BK (2008). „A functional variable number of tandem repeats is located at the 5' flanking region of the human secretin gene plays a downregulatory role in expression.”. J. Mol. Neurosci. 36 (1-3): 125—31. PMID 18566919. doi:10.1007/s12031-008-9083-5.
GG, Nussdorfer; BahÃ§elioglu M; G, Neri; LK, Malendowicz (2000). „Secretin, glucagon, gastric inhibitory polypeptide, parathyroid hormone, and related peptides in the regulation of the hypothalamus- pituitary-adrenal axis.”. Peptides. 21 (2): 309—24. PMID 10764961. doi:10.1016/S0196-9781(99)00193-X.
L, Lossi; L, Bottarelli; ME, Candusso (2004). „Transient expression of secretin in serotoninergic neurons of mouse brain during development.”. Eur. J. Neurosci. 20 (12): 3259—69. PMID 15610158. doi:10.1111/j.1460-9568.2004.03816.x.
Lee SM, Yung WH, Chen L, Chow BK (2005). „Expression and spatial distribution of secretin and secretin receptor in human cerebellum.”. Neuroreport. 16 (3): 219—22. PMID 15706223. doi:10.1097/00001756-200502280-00003.
IP, Lam; LT, Lee; HS, Choi (2009). „Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP).”. Am. J. Physiol. Gastrointest. Liver Physiol. 297 (1): G90—7. PMC 2711755 . PMID 19372104. doi:10.1152/ajpgi.00094.2009.
T, Yamagata; S, Aradhya; M, Mori (2002). „The human secretin gene: fine structure in 11p15.5 and sequence variation in patients with autism.”. Genomics. 80 (2): 185—94. PMID 12160732. doi:10.1006/geno.2002.6814.
Lee LT, Tan-Un KC, Chow BK (2006). „Retinoic acid-induced human secretin gene expression in neuronal cells is mediated by cyclin-dependent kinase 1.”. Ann. N. Y. Acad. Sci. 1070: 393—8. PMID 16888198. doi:10.1196/annals.1317.051.
P, Onori; C, Wise; E, Gaudio (2010). „Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-dependent signaling mechanisms of secretin receptor.”. Int. J. Cancer. 127 (1): 43—54. PMID 19904746. doi:10.1002/ijc.25028.
LT, Lee; Tan-Un KC; RT, Pang (2004). „Regulation of the human secretin gene is controlled by the combined effects of CpG methylation, Sp1/Sp3 ratio, and the E-box element.”. Mol. Endocrinol. 18 (7): 1740—55. PMID 15118068. doi:10.1210/me.2003-0461.
Lu Y, Owyang C (2009). „Secretin-induced gastric relaxation is mediated by vasoactive intestinal polypeptide and prostaglandin pathways.”. Neurogastroenterol. Motil. 21 (7): 754—e47. PMC 2743409 . PMID 19239625. doi:10.1111/j.1365-2982.2009.01271.x.
Gandhi S, Rubinstein I, Tsueshita T, Onyuksel H (2002). „Secretin self-assembles and interacts spontaneously with phospholipids in vitro.”. Peptides. 23 (1): 201—4. PMID 11814635. doi:10.1016/S0196-9781(01)00596-4.
JW, Love (2008). „Peptic ulceration may be a hormonal deficiency disease.”. Med. Hypotheses. 70 (6): 1103—7. PMID 18280672. doi:10.1016/j.mehy.2007.12.011.
Lam IP, Lee LT, Choi HS, Chow BK (2006). „Localization of small heterodimer partner (SHP) and secretin in mouse duodenal cells.”. Ann. N. Y. Acad. Sci. 1070: 371—5. PMID 16888194. doi:10.1196/annals.1317.047.
Luttrell, L. M. (2008). „Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.”. Mol. Biotechnol. 39 (3): 239—64. PMID 18240029. doi:10.1007/s12033-008-9031-1.
K, Du; A, Couvineau; Rouyer-Fessard C (2002). „Human VPAC1 receptor selectivity filter. Identification of a critical domain for restricting secretin binding.”. J. Biol. Chem. 277 (40): 37016—22. PMID 12133828. doi:10.1074/jbc.M203049200.
Portela-Gomes GM, Johansson H, Olding L, Grimelius L (1999). „Co-localization of neuroendocrine hormones in the human fetal pancreas.”. Eur. J. Endocrinol. 141 (5): 526—33. PMID 10576771. doi:10.1530/eje.0.1410526.
Mutoh H, Ratineau C, Ray S, Leiter AB (2000). „Review article: transcriptional events controlling the terminal differentiation of intestinal endocrine cells.”. Aliment. Pharmacol. Ther. 14 Suppl 1: 170—5. PMID 10807420.