环戊丙酸雌二醇 读音 ES -trə-DY -ohl sih-PY -oh-nate[ 1] 商品名 Depo-Estradiol, Depofemin, Estradep, many others 其他名稱 EC; E2C; Estradiol cipionate; Estradiol cyclopentylpropionate; ECP; Estradiol 17β-cyclopentylpropionate; Estradiol 17β-cyclopentanepropionate 给药途径 Intramuscular injection , subcutaneous injection 藥物類別 Estrogen ; Estrogen ester ATC碼 法律規範
生物利用度 IM : High血漿蛋白結合率 Estradiol: ~98% (to albumin and SHBG [ 2] [ 3] 药物代谢 Cleavage via esterase s in the liver , blood , and tissue s代謝產物 Estradiol , cypionic acid , and metabolite s of estradiol生物半衰期 IM (aqueous suspension ): 8–10 days[ 4] 作用時間 IM (oil ): 5 mg ≈ 11–14 days[ 5] IM (aqueous suspension ): 5 mg ≈ 14–24 days[ 4] 排泄途徑 Urine
[(8R ,9S ,13S ,14S ,17S )-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a ]phenanthren-17-yl] 3-cyclopentylpropanoate
CAS号 313-06-4 PubChem CID DrugBank ChemSpider UNII KEGG ChEBI ChEMBL CompTox Dashboard (EPA ) ECHA InfoCard 100.005.672 化学式 C 26 H 36 O 3 摩尔质量 396.57 g·mol−1 3D模型（JSmol 熔点 151至152 °C（304至306 °F）
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2OC(=O)CCC4CCCC4)CCC5=C3C=CC(=C5)O
InChI=1S/C26H36O3/c1-26-15-14-21-20-10-8-19(27)16-18(20)7-9-22(21)23(26)11-12-24(26)29-25(28)13-6-17-4-2-3-5-17/h8,10,16-17,21-24,27H,2-7,9,11-15H2,1H3/t21-,22-,23+,24+,26+/m1/s1
Key:UOACKFBJUYNSLK-XRKIENNPSA-N
环戊丙酸雌二醇 （英語：Estradiol cypionate ，缩写EC ，商品名有Depo-Estradiol 等）是一种有机化合物 ，化学式C ，属于一种雌二醇 的17β酯 ，其复方药 環戊丙酸雌二醇/醋酸甲羥孕酮 列入世界卫生组织基本药物标准清单 。
^ Estradiol: Uses, Dosage & Side Effects . Drugs.com. [21 April 2023] . ^ Stanczyk FZ, Archer DF, Bhavnani BR. Ethinyl estradiol and 17β-estradiol in combined oral contraceptives: pharmacokinetics, pharmacodynamics and risk assessment. Contraception. June 2013, 87 (6): 706–727. PMID 23375353 doi:10.1016/j.contraception.2012.12.011 ^ Gupta MK, Chia SY. Ovarian Hormones: Structure, Biosynthesis, Function, Mechanism of Action, and Laboratory Diagnosis . Falcone T, Hurd WW (编). Clinical Reproductive Medicine and Surgery. Elsevier Health Sciences. 2007: 22. ISBN 978-0-323-03309-1 Arredondo F, Liu JH. Menopause . Falcone T, Hurd WW (编). Clinical Reproductive Medicine and Surgery. Elsevier Health Sciences. 2007: 362,388. ISBN 978-0-323-03309-1 ^ 4.0 4.1 Thurman A, Kimble T, Hall P, Schwartz JL, Archer DF. Medroxyprogesterone acetate and estradiol cypionate injectable suspension (Cyclofem) monthly contraceptive injection: steady-state pharmacokinetics. Contraception. June 2013, 87 (6): 738–43. PMID 23265980 doi:10.1016/j.contraception.2012.11.010 ^ Oriowo MA, Landgren BM, Stenström B, Diczfalusy E. A comparison of the pharmacokinetic properties of three estradiol esters. Contraception. April 1980, 21 (4): 415–24. PMID 7389356 doi:10.1016/S0010-7824(80)80018-7
